404933-13-7

Upstream product

• 372172-32-2 C₁₇H₁₇NO₄ 
• 117507-63-8 2-amino-N-((furan-2-yl)methyl)benzamide. 
• 103-90-2 4-acetaminophenol 
• 52577-09-0 3-(chloromethyl)-4-methoxybenzaldehyde 

Downstream Products

• 1013749-05-7 N-(4-(5-(3-(furan-2-ylmethyl)-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methoxybenzyloxy)phenyl)acetamide 

Relevant academic research and scientific papers

LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS

PROBLEM TO BE SOLVED: To provide oxo-hydroquinazolines that are useful as selective thyroid stimulating hormone receptor (TSHR) agonists and may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder. SOLUTION: The present invention provides compounds represented by a formula in the figure. [R1-R4 are each independently H, hydroxyl or the like; R5 is -CH2-Ph; A is -N=C(R15)- (where a bond at the left end bonds to the benzene ring in the formula and a bond at the right end bonds to the nitrogen heteroatom in the formula) or the like; and R15 is phenyl having specific substituents.] COPYRIGHT: (C)2015,JPOandINPIT

LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS

Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.

LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS

Disclosed are oxo-hydroquinazolines of formula I that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.