404936-52-3

Basic information

• Product Name: (3S,5R)-3-[3-(benzyloxy)propyl]-5-hydroxy-14-methoxy-3,4,5,6,7,8-hexahydro-1H-2-benzoxacyclododecin-1-one
• Synonyms: (3S,5R)-3-[3-(benzyloxy)propyl]-5-hydroxy-14-methoxy-3,4,5,6,7,8-hexahydro-1H-2-benzoxacyclododecin-1-one
• CAS NO: 404936-52-3
• Molecular Weight: 424.537
• Mol File: 404936-52-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3S,5R)-3-[3-(benzyloxy)propyl]-5-hydroxy-14-methoxy-3,4,5,6,7,8-hexahydro-1H-2-benzoxacyclododecin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,5R)-3-[3-(benzyloxy)propyl]-5-hydroxy-14-methoxy-3,4,5,6,7,8-hexahydro-1H-2-benzoxacyclododecin-1-one(404936-52-3)
• EPA Substance Registry System: (3S,5R)-3-[3-(benzyloxy)propyl]-5-hydroxy-14-methoxy-3,4,5,6,7,8-hexahydro-1H-2-benzoxacyclododecin-1-one(404936-52-3)

Safety Data

• Hazardous Substances Data: 404936-52-3(Hazardous Substances Data)

Upstream product

• 4136-95-2 2,4,6-trichlorobenzoyl chloride 
• 404936-51-2 2-[(1E,6R,8S)-11-(benzyloxy)-6,8-dihydroxy-1-undecenyl]-6-methoxybenzoic acid 
• 19131-21-6 (2S)-pentane-1,2,5-triol 
• 404936-41-0 (6S)-1-triethylsilyloxy-4,4-S-S-propylidene-6-hydroxy-9-benzyloxy-nonane 
• 404936-45-4 (4R,6S)-1-methylsulfonyloxy-4,6-O-isopropylidene-9-(benzyloxy)-4,6-nonanediol 
• 404936-47-6 (4S,6R)-1-benzyloxy-4,6-O-isopropylidene-10-undecyne-4,6-diol 
• 404936-46-5 (4R,6S)-1-iodo-4,6-O-isopropylidene-9-(benzyloxy)-4,6-nonanediol 
• 404936-44-3 (4R,6S)-4,6-O-isopropylidene-9-(benzyloxy)-1,4,6-nonanetriol 
• 404936-43-2 (4R,6S)-9-(benzyloxy)-1,4,6-nonanetriol 
• 404936-42-1 (6S)-1,6-dihydroxy-9-benzyloxy-nonan-4-one 
• 158110-04-4 (2S)-1,2-epoxy-5-benzyloxy-pentane 
• 158010-31-2 (2S)-1,2-O-isopropylidene-5-O-benzylpentane-1,2,5-triol 
• 171335-60-7 (2S)-5-O-benzylpentane-1,2,5-triol 
• 51268-87-2 (4S)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propan-1-ol 

Relevant articles and documents

Applications of size-selective macrolactonizations to the synthesis of benzolactone-enamide core structures

By utilizing Stille cross-coupling reactions four benzoic acid derivatives (18, 32, 46, 66) were prepared that carry a side chain with two secondary hydroxy groups. It could be shown that the hydroxy functions can be distinguished by size-selective macrolactonization reactions. Thus, 12-membered lactones 19 and 33 are favored over their 11-membered lactone counterparts 20 and 34, respectively, albeit with a low (60:40-70:30) ratio. The selectivity is much more pronounced if there is a competition between a 12- and 10-membered lactone. This could be shown with the two lactones 47 and 67. The 12-membered lactones 33, 47, and 67 represent core structures for analogs of the benzolactone enamides. The macrolactonization reactions were performed under Yamaguchi conditions.