404936-90-9Relevant academic research and scientific papers
Pyridazines. Part 30:1 Palladium-catalysed synthesis of 5-substituted 6-phenyl-3(2H)-pyridazinones asissted by a retro-ene transformation
Coelho, Alberto,Ravi?a, Enrique,Sotelo, Eddy
, p. 2062 - 2064 (2002)
The efficient one-pot functionalization, through palladium-catalysed reactions, of position 5 of the 6-phenyl-3(2H)-pyridazinone system has been performed using a retro-ene-assisted fragmentation. This route allows access through a short synthetic sequenc
Pyridazine derivatives. Part 40: Reactivity of 5-alkynylpyridazin-3(2H)- ones toward hydrochloric acid
Coelho, Alberto,Novoa, Héctor,Peeters, Oswald M.,Blaton, Norbert,Alvarado, Mario,Sotelo, Eddy
, p. 4785 - 4791 (2005)
5-Alkynylpyridazin-3(2H)-ones or 5-(2-chloroalkenyl)pyridazin-3(2H)-ones were isolated during the cleavage of the methoxymethyl group in a series of 5-alkynyl-2-methoxymethylpyridazin-3(2H)-ones by treatment with hydrochloric acid. The efficient and selective cleavage of the methoxymethyl group in these compounds can be performed under mild conditions by employing aluminium chloride.
Pyridazines. Part 36: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones
Coelho, Alberto,Sotelo, Eddy,Fraiz, Nuria,Yanez, Matilde,Laguna, Reyes,Cano, Ernesto,Ravina, Enrique
, p. 321 - 324 (2007/10/03)
A convenient and efficient palladium-catalysed retro-ene-assisted method has been developed to prepare a series of 5-substituted-6-phenyl-3(2H)- pyridazinones as potential antiplatelet drugs. The most active compounds were those that contain a 3-phenyl-3-
Pyridazine derivatives. Part 33: Sonogashira approaches in the synthesis of 5-substituted-6-phenyl-3(2H)-pyridazinones
Coelho, Alberto,Sotelo, Eddy,Ravi?a, Enrique
, p. 2477 - 2484 (2007/10/03)
Several 6-phenyl-3(2H)-pyridazinones bearing different alkynyl groups at position 5 have been prepared by a palladium-catalysed Sonogashira cross-coupling reaction. An interesting base-promoted electronically permitted isomerization has been observed duri
Pyridazines. Part 25: Efficient and selective deprotection of pharmacologically useful 2-MOM-pyridazinones using Lewis acids
Sotelo, Eddy,Coelho, Alberto,Ravi?a, Enrique
, p. 8633 - 8636 (2007/10/03)
An efficient and selective procedure for the cleavage of a methoxymethyl group at the 2-position in acid-sensitive pyridazinones is presented. Deprotection with Lewis acids (boron tribromide or aluminium chloride) affords 3(2H)-pyridazinones under mild co
