404961-35-9

Upstream product

• 13871-68-6 p-aminophenyl acetate 
• 100-02-7 4-nitro-phenol 
• 63700-05-0 1,2;5,6-dianhydro-3,4-O-isopropylidene-D-mannitol 
• 51432-65-6 1,6-di-O-benzoyl-3,4-O-isopropylidene-2,5-di-O-p-toluenesulphonyl-D-mannitol 
• 51432-64-5 1,6-di-O-benzoyl-3,4-di-O-isopropylidene-D-mannitol 
• 3969-59-3 mannitol triacetonide 
• 3969-84-4 3,4-di-O-isopropylidene-D-mannitol 
• 830-03-5 4-nitrophenol acetate 
• 53754-41-9 1,6-di-O-(p-toluenesulfonyl)-3,4-O-isopropylidene-D-mannitol 

Downstream Products

• 404961-36-0 (3aR,4R,8R,8aR)-6-(4-Hydroxy-phenyl)-2,2-dimethyl-hexahydro-1,3-dioxa-6-aza-azulene-4,8-diol 

Relevant academic research and scientific papers

Synthesis and DNA-binding ability of pyrrolo[2,1-c][1,4]benzodiazepine- azepane conjugates

A series of pyrrolobenzodiazepine-azepane conjugates linked through different alkane spacers have been prepared and their DNA thermal denaturation studies have been carried out. One of the compound (4b), elevates the DNA helix melting temperature of the CT-DNA by 2.0°C after incubation for 36 h at 37°C.

Polyhydroxylated azepanes as new motifs for DNA minor groove binding agents

The synthesis of 1,3-bis-[3,4,5,6-tetrahydroxyazepane-N-p-phenoxy] and 1,3-bis-[3,4,5,6-tetrahydroxyazepane-N-p-benzyloxy] propanes is reported. These compounds have been prepared to investigate the potential of incorporating iminosugars as useful recognition elements in DNA minor groove binding agents. The compounds were shown to have very moderate binding affinities for DNA in thermal denaturation and ethidium bromide displacement assays when compared with propamidine. They were also found to possess some in vitro anticancer activity that did not correlate with their DNA binding affinity.