404963-75-3

Upstream product

• 200423-20-7 4-Chloro-3-hydroxysulfinylbenzoic acid 
• 74-11-3 para-chlorobenzoic acid 
• 34263-58-6 4-Amino-3-methylsulfonylbenzoesaeure 
• 51522-07-7 3-methylsulphonyl-4-chlorobenzoic acid 
• 166964-33-6 5-chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride 
• 404964-28-9 methyl 4-amino-3-methanesulfonylbenzoate 
• 2494-79-3 4-chloro-3-(chlorosulfonyl)benzoic acid 

Relevant academic research and scientific papers

Structure-activity relationship of benzo[b]thiophene-2-sulfonamide derivatives as novel human chymase inhibitors

We have identified a new class of chymase inhibitor through a substituent analysis of MWP00965, which we previously discovered by in silico screening. TY-51076 (7) showed high potency (IC50=56 nM) and excellent selectivity for chymase compared to chymotrypsin and cathepsin G (>400-fold). The synthesis and structure-activity relationship of this class are described.

N-substituted benzothiophenesulfonamide derivatives

The present invention relates to an N-substituted benzothiophenesulfonamide derivative or a pharmaceutically acceptable salt thereof and applications thereof. Furthermore, it provides an agent for preventing or treating cardiac or circulatory disease and