40531-95-1

Upstream product

• 28587-05-5 3-dimethylamino-1(4-chloro-phenyl)-2-propen-1-one 
• 99-91-2 para-chloroacetophenone 
• 4996-21-8 1-(4-chloro-phenyl)-2,2-dihydroxy-ethanone 
• 124-40-3 dimethyl amine 

Downstream Products

• 76579-51-6 2-(4-chlorophenyl)-N,N-dimethylethanethioamide 
• 1395057-60-9 C₁₀H₁₂ClNOS 
• 185851-69-8 2-(4-chlorophenyl)-N,N-dimethyl-2-thioethane-thioamide 

Relevant academic research and scientific papers

Na2S-mediated thionation: An efficient access to secondary and tertiary α-ketothioamides via Willgerodt-Kindler reaction of readily available arylglyoxals with amines

The task of this paper is to provide an efficient process for synthesis of secondary and tertiary α-ketothioamides via Willgerodt-Kindler reaction of readily available arylglyoxals with amines using Na2S as an effective catalyst. A plausible role for Na2S in the reaction of arylglyoxals with primary amines is proposed.

Synthesis of α-Keto Thioamides by Metal-Free C-C Bond Cleavage in Enaminones Using Elemental Sulfur

An unprecedented method for cleaving the C-C bond in N,N-disubstituted enaminones in the presence of elemental sulfur and N,N-dimethyl-4-aminopyridine is disclosed. Without using any metal catalyst or additive, the cascade functionalization of both C?C an

Summary - α-Thioxothioamides : [4 + 2] cycloaddition reactions with dimethyl acetylenedicarboxylate and methyl propiolate

The title compounds are prepared from methyl ketones through a three-step reaction: chloration with thionyl chloride; amination of the resulting α-chloro-β-oxosulfenyl chlorides; and thionation of α-oxothioamides with Lawesson's reagent. Two competitive h