40534-73-4

Upstream product

• 40534-52-9 N-(4-fluorobenzyl)isatoic anhydride 
• 40800-64-4 3-methylsulfanyl-1,3-dihydroindol-2-one 
• 459-57-4 4-fluorobenzaldehyde 
• 118-92-3 anthranilic acid 

Downstream Products

• 645418-65-1 7-[2-(4-fluorobenzylamino)-benzoylamino]-4,4-dimethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

SUBSTITUTED ANTHRANILIC AMIDE DERIVATIVES AND METHODS OF USE

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

The Chemistry of 2H-1,3-Benzoxazine-2,4-(1H)dione (Isatoic Anhydride). 8. A One Step Synthesis of the Quinindoline Ring System and Related Compounds

The reaction between N-substituted isatoic anhydrides and the carbanion generated from 3-methylthiooxindole to produce the quinindoline ring skeleton is discussed.Analogous reactions of azaisatoic anhydride 6 and tricyclic anhydride 8 produces the 4-aza analog 7 and pentacycle 9.Some spectral data is also described.