40545-37-7

Upstream product

• 84228-49-9 methyl 2-amino-5-chloro-3-nitrobenzoate 
• 7664-41-7 ammonia 
• 313279-12-8 2-amino-3-nitro-benzamide 
• 573692-70-3 5-chloro-3-nitro-2-(2,2,2-trifluoroacetyl)aminobenzoic acid 
• 648939-10-0 5-chloro-2-(2,2,2-trifluoroacetyl)aminobenzoic acid 
• 635-21-2 5-chloroanthranilic acid 
• 6324-51-2 2-amino-5-chloro-3-nitrobenzoic acid 

Downstream Products

• 573692-41-8 2,3-diamino-5-chlorobenzamide 

Relevant academic research and scientific papers

Fluoroalkyl-substituted 2-amidobenzimidazoles and their effect on plant growth

Use of fluoroalkyl-substituted 2-amidobenzimidazoles of the formula (I), or agriculturally acceptable salts thereof, for the treatment of plants for inducing growth regulating responses on plants, on seeds from which they grow or on the locus in which they grow in their normal habitat and in the absence of extraordinary environmental conditions and which result in superior growth of these treated plants, certain parts of these plants or, more generally, crop yield.

Fluoroalkyl-substituted 2-amidobenzimidazoles

Use of fluoroalkyl-substituted 2-amidobenzimidazoles of the formula (I), or salts thereof, for enhancing stress tolerance in plants to abiotic stress, especially for strengthening plant growth and/or for increasing plant yield, and selected processes for preparing such fluoroalkyl-substituted 2-amidobenzimidazoles of the formula (I).

Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer

We have developed a series of cyclic amine-containing benzimidazole carboxamide poly(ADP-ribose)polymerase (PARP) inhibitors, with good PARP-1 enzyme potency, as well as cellular potency. These efforts led to the identification of a lead preclinical candi

SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS

The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.

SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS

Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of For

1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS

Compounds having formula (I), inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).

2-Substituted-1 H-benzimidazile-4-carboxamides are PARP inhibitors

Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), method of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compound of Formula (I).

1H-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent PARP inhibitors

Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of For

Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists

A series of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones (QXs) related to licostinel (Acea 1021) was synthesized and evaluated as antagonists for the glycine site of the N-methyl-D-asparate (NMDA) receptor. The in vitro potency of these