6324-51-2Relevant articles and documents
Composition containing pyridalyl and tolfenpyrad
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, (2021/09/08)
The invention discloses a composition containing pyridalyl and tetratolfenpyrad, and belongs to the technical field of pesticide synthesis. The composition comprises the following raw materials by weight: 1-50% of pyridalyl, 1-50% of tetratolfenpyrad, 5-15% of a synergist, 0.1-3% of polyethylene glycol, and the balance of water; wherein the pyridalyl and the tetratolfenpyrad have a certain insecticidal effect, a synergist is prepared in the preparation process of the composition, the synergist is used for reducing an intermediate 6 to prepare an intermediate 7, the intermediate 7 reacts with phosgene to prepare an intermediate 8, the intermediate 8 reacts with 2, 2, 2-trifluoroethanol to prepare an intermediate 9, the intermediate 9 is subjected to microspheroidizing treatment; and thus, the synergist is prepared, the synergist can block nerve conduction to enable insects to die, then the insecticidal effect of the composition is further improved, and the pesticide effect is further prolonged through microspheroidizing.
COMPOUNDS USEFUL AS ANTIBIOTIC TOLERANCE INHIBITORS
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Page/Page column 67, (2014/11/13)
The disclosure provides compounds and pharmaceutical compositions of the compounds useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds and salts of general Formula VIII Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of Pseudomonas aeruginosa. Methods of treating bacterial infections in a patient, including Pseudomonas aeruginosa infections, are also provided by the disclosure.
Fluoroalkyl-substituted 2-amidobenzimidazoles and their effect on plant growth
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Paragraph 0062-0063, (2013/03/26)
Use of fluoroalkyl-substituted 2-amidobenzimidazoles of the formula (I), or agriculturally acceptable salts thereof, for the treatment of plants for inducing growth regulating responses on plants, on seeds from which they grow or on the locus in which they grow in their normal habitat and in the absence of extraordinary environmental conditions and which result in superior growth of these treated plants, certain parts of these plants or, more generally, crop yield.
Fluoroalkyl-substituted 2-amidobenzimidazoles
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Page/Page column 13, (2011/10/02)
Use of fluoroalkyl-substituted 2-amidobenzimidazoles of the formula (I), or salts thereof, for enhancing stress tolerance in plants to abiotic stress, especially for strengthening plant growth and/or for increasing plant yield, and selected processes for preparing such fluoroalkyl-substituted 2-amidobenzimidazoles of the formula (I).
DIHYDROOROTATE DEHYDROGENASE INHIBITORS
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Page/Page column 96, (2010/11/03)
The invention relates to compounds of formula (I) wherein R1, R2, X1, X2, Y, Ra, Rb, Q have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.
Process development for ABT-472, a benzimidazole PARP inhibitor
Barkalow, Jufang H.,Breting, Jeffrey,Gaede, Bruce J.,Haight, Anthony R.,Henry, Rodger,Kotecki, Brian,Mei, Jianzhang,Pearl, Kurt B.,Tedrow, Jason S.,Viswanath, Shekhar K.
supporting information, p. 693 - 698 (2012/12/29)
A nine-step convergent process was developed for the synthesis of ABT-472, a benzimidazole PARP inhibitor. The identity and origin of several impurities were determined, and the process was modified to reduce or eliminate these impurities. A number of safety and control issues were investigated. The original synthesis was shortened to 9 steps and streamlined while maintaining a convergent strategy. A stable salt was selected, and control of the API solid form was established. The process was successfully scaled up to provide 8.5 kg of final product of >99% purity in 33% yield over 9 steps.
Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists
Zhou, Zhang-Lin,Kher, Sunil M.,Cai, Sui Xiong,Whittemore, Edward R.,Espitia, Stephen A.,Hawkinson, Jon E.,Tran, Minhtam,Woodward, Richard M.,Weber, Eckard,Keana, John F. W.
, p. 1769 - 1780 (2007/10/03)
A series of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones (QXs) related to licostinel (Acea 1021) was synthesized and evaluated as antagonists for the glycine site of the N-methyl-D-asparate (NMDA) receptor. The in vitro potency of these
Fused Tetracyclic quinoxalines from reactions of o-phenylenediamines in polyphosphoric acid
Deady, Leslie W.,Kaye, Anthony J.
, p. 473 - 478 (2007/10/03)
The condensation of 2,3-diaminobenzoic acid and the 5-chloro derivative with o-hydroxyphenylglyoxylic acid, isatin and benzothiophen-2,3-dione in polyphosphoric acid leads to the appropriate tetracycles. Isomeric products are formed from these unsymmetric
(R)-3-(6-chloro-1-isopropylbenzimidazole-4-carboxamido)quinuclidine: A high affinity ligand for the (R)-zacopride binding site
Flippin,Carter,Berger,Clark,Bonhaus,Leung,Eglen
, p. 477 - 480 (2007/10/03)
The (R)-3-amido quinuclidine 6 (RS-16566) was found to be a high affinity ligand for the (R)-zacopride binding site.
Process for preparing 5-halo-2,3-phenylenediamine-1-carboxylic acid
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, (2008/06/13)
Method of preparing 5-halo-2,3-phenylenediamine-1-carboxylic acids having the following formula: SPC1 Wherein X is Cl, Br or F by reacting a 2,5-dihalo-3-nitrobenzoic acid with ammonium hydroxide to yield 5-halo-3-nitro anthranilic acid followed by a redu