40566-92-5Relevant articles and documents
Tert-Butyl Iodide Mediated Reductive Fischer Indolization of Conjugated Hydrazones
Ito, Yuta,Ueda, Masafumi,Takeda, Norihiko,Miyata, Okiko
, p. 2616 - 2619 (2016/02/26)
A novel reductive Fischer indolization of readily available N-aryl conjugated hydrazones with tert-butyl iodide has been developed. In this reaction, tert-butyl iodide is used as anhydrous HI source, and the generated HI acts as a Br?nsted acid and a reducing agent. This operationally simple method allows access to various indole derivatives. Furthermore, the procedure can be applied to the synthesis of biologically active compounds.