40575-72-2

Upstream product

• 486-66-8 daidzein 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 40575-74-4 [3-(4-Carboxymethoxy-phenyl)-4-oxo-4H-chromen-7-yloxy]-acetic acid 

Relevant academic research and scientific papers

Application of isoflavone derivative in inhibiting human cervical carcinoma Hela cell proliferation

The invention provides application of an isoflavone derivative with the structure as shown in formula (I) in the specification in inhibiting human cervical carcinoma Hela cell proliferation. The isoflavone derivative provided by the invention is a carboxylate derivative of isoflavone, has a relatively good inhibition property for human cervical carcinoma Hela cell proliferation, and can be basis of novel medicines for inhibiting cervical carcinoma cell proliferation.

Application of isoflavone derivative in inhibiting lung adenocarcinoma A549 cell proliferation

The invention provides the application of an isoflavone derivative of the structure as shown in the formula (I) in inhibiting lung adenocarcinoma A549 cell proliferation. The isoflavone derivative is an amides derivative of isoflavone, can well inhibit human lung adenocarcinoma cell proliferation, and can serve as the basis of a new flavonoid drug for resisting lung carcinoma cell proliferation.

Isoflavone derivative and application thereof to erythrocytic hemolysis prevention

The invention provides application of an isoflavone derivative in the structure in the formula (I) to erythrocytic hemolysis prevention.The isoflavone derivative has good water solubility, can well remove free radicals, and has an erythrocytic hemolysis prevention function.Experiment results show that the isoflavone derivative has a good erythrocytic hemolysis prevention function.

ALDH-2 INHIBITORS IN THE TREATMENT OF PSYCHIATRIC DISORDERS

Disclosed are isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for use treating in mammals suffering from psychiatric disorders such as, for example, depression, generalized anxiety, social phobia, panic disorder, and sleep disorders.

ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION

Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.

Synthesis of potential antidipsotropic isoflavones: Inhibitors of the mitochondrial monoamine oxidase - Aldehyde dehydrogenase pathway

Recently we have shown that daidzin, the major active principle of an ancient herbal treatment for quot;alcohol addictionquot; suppresses ethanol intake in alcohol-preferring laboratory animals. Further, we have identified the monoamine oxidase (MAO) - aldehyde dehydrogenase (ALDH-2) pathway of the mitochondria as the potential site of action of daidzin. Daidzin analogues that potently inhibit ALDH-2 but have no or little effect on MAO are most antidipsotropic, whereas those that also inhibit MAO exhibit little, if any, antidipsotropic activity. Therefore, in the design and synthesis of more potent antidipsotropic analogues, structural features important for the inhibition of both ALDH-2 and MAO must be taken into consideration. To gain further information on the structure-activity relationships at the inhibitor binding sites of ALDH-2 and MAO, we prepared 44 analogues of daidzin and determined their potencies for ALDH-2 and MAO inhibition. Results indicate that a sufficient set of criteria for a potent antidipsotropic analogue is an isoflavone with a free 4′-OH function and a straight-chain alkyl substituent at the 7 position that has a terminal polar function such as -OH, -COOH, or -NH2. The preferable chain lengths for the 7-O-ω-hydroxy, 7-O-ω-carboxy, and 7-O-ω-amino subsitutents are 2 ≤ n ≤ 6, 5 ≤ n ≤ 10, and n ≥ 4, respectively. Analogues that meet these criteria have increased potency for ALDH-2 inhibition and/or decreased potency for MAO inhibition and therefore are likely to be potent antidipsotropic agents.