40611-83-4Relevant academic research and scientific papers
SUBSTITUTED [(5H-PYRROLO[2,1-c][1,4]BENZODIAZEPIN-11-YL)PIPERAZIN-1-YL]-2,2-DIMETHYLPROPANOIC ACID COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS
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, (2012/08/27)
A dual H1/5-HT2A receptor antagonist of the formula: its uses, and methods for its preparation are described.
Synthesis of alkylpyrroles by use of a vinamidinium salt
Wright, Mathew T.,Carroll, David G.,Smith, Timothy M.,Smith, Stanton Q.
experimental part, p. 4150 - 4152 (2010/08/19)
The synthesis of alkyl-substituted 2-pyrrolecarboxylate esters has been accomplished by the condensation reaction of a symmetrical vinamidinium salt and glycine ester derivatives.
Conversion of 4-oxoproline esters to 4-substituted pyrrole-2-carboxylic acid esters
Arakawa, Yasushi,Yagi, Naomi,Arakawa, Yukimi,Tanaka, Ken-Ichi,Yoshifuji, Shigeyuki
experimental part, p. 167 - 176 (2009/09/25)
The Grignard, Wittig, Tebbe, Horner-Emmons, and Reformatsky reactions of the 4-oxoproline esters gave the corresponding 4-alylated or 4-alkylidenated products, respectively. The products were properly treated with bases to cause aromatization, giving 4-su
Pyrroles from 3-Alkoxyacroleins and CH-acidic α-Aminoacetic Acid Derivatives
Walizei, Gul Hassan,Breitmaier, Eberhard
, p. 337 - 340 (2007/10/02)
2-Alkoxycarbonylpyrroles and 2-cyanopyrroles 4 are prepared in a one-step synthesis by vinylogous amidation of 3-alkoxyacroleins 1 with glycine esters 2a-c and aminoacetonitrile (2d), followed by base-catalyzed cyclodehydration of the intermediate 3-aminoacroleins 3.The 3-hydroxypropyl function can be introduced into the pyrrole ring by using 3,4-dihydro-2H-pyran-5-carbaldehyde (5) as a cyclic 3-alkoxyacrolein.
