654074-97-2

Basic information

• Product Name: 2(1H)-Quinolinone, 4-(3-chlorophenyl)-6-[(4-chlorophenyl)(1-methyl-1H-tetrazol-5-yl)methyl]- 1-methyl-
• CAS NO: 654074-97-2
• Molecular Formula: C25H19Cl2N5O
• Molecular Weight: 476.365
• Mol File: 654074-97-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2(1H)-Quinolinone, 4-(3-chlorophenyl)-6-[(4-chlorophenyl)(1-methyl-1H-tetrazol-5-yl)methyl]- 1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinolinone, 4-(3-chlorophenyl)-6-[(4-chlorophenyl)(1-methyl-1H-tetrazol-5-yl)methyl]- 1-methyl-(654074-97-2)
• EPA Substance Registry System: 2(1H)-Quinolinone, 4-(3-chlorophenyl)-6-[(4-chlorophenyl)(1-methyl-1H-tetrazol-5-yl)methyl]- 1-methyl-(654074-97-2)

Safety Data

• Hazardous Substances Data: 654074-97-2(Hazardous Substances Data)

Upstream product

• 654074-96-1 4-(3-chloro-phenyl)-6-[(4-chloro-phenyl)-(1H-tetrazol-5-yl)-methyl]-1-methyl-1H-quinolin-2-one 
• 74-88-4 methyl iodide 
• 406161-89-5 (4-chloro-phenyl)-[4-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-quinolin-6-yl]-acetonitrile 
• 192187-33-0 R₁₀₄₂₀₉ 

Relevant articles and documents

4-Methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the Farnesyltransferase inhibitor ZARNESTRA

Replacement of the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA series by a 4-methyl-1,2,4-triazol-3-yl group gave us compounds with similar structure-activity relationship profiles showing that this triazole is potentially a good surrogate to imidazole for farnesyltransferase inhibition.