406169-90-2

Usage

Chemical class

Quinolinone

Quinoline ring structure

Present

Hydroxy group

At the 7th position

Methoxymethyl group

At the 4th position

Methyl group

At the 6th position

Potential pharmaceutical applications

Uncertain, requires further research and testing

Ability to interact with biological targets

Possible, due to structural features

Upstream product

• 95-80-7 4-methylbenzene-1,3-diamine 
• 66762-68-3 ethyl 4-methoxy-3-oxobutanoate 
• 406169-89-9 7-amino-4-methoxymethyl-6-methylquinolin-2-one 

Relevant academic research and scientific papers

Synthesis and biological evaluation of a new furo[2,3-h]quinolin-2(1H)-one

A new furoquinolinone derivative, namely 4-hydroxymethyl-1,6,8-trimethylfuro[2,3-h]quinolin-2(1H)-one (HOFQ), was synthesized and its biological activity studied. By UVA activation, HOFQ induced strong antiproliferative effects in Ehrlich ascite cells, which lost their ability to transmit the tumor by transplantation. HOFQ exhibited poor genotoxicity and absence of skin phototoxicity. Actually, HOFQ sensitization forms DNA-protein cross-linkages but not interstrands cross-links. Therefore, HOFQ appears to be a new promising drug for PUVA photochemotherapy and photopheresis.