406195-56-0Relevant articles and documents
A new asymmetric synthesis of the anti-tumor alkaloid (R)-(+)-crispine A
Allin, Steven M.,Gaskell, Sean N.,Towler, Joannah M. R.,Bulman Page, Philip C.,Saha, Basu,McKenzie, Michael J.,Martin, William P.
, p. 8972 - 8975 (2007)
(Chemical Equation Presented) We report a novel, facile, and asymmetric approach for the synthesis of the anti-tumor alkaloid (+)-crispine A via a highly diastereoselective N-acyliminium cyclization reaction as a key synthetic step.
Stereoselective synthesis of the pyrroloisoquinoline ring system
Allin, Steven M.,James, Stella L.,Martin, William P.,Smith, Timothy A.D.,Elsegood, Mark R.J.
, p. 3029 - 3036 (2007/10/03)
In this paper we report a facile and stereoselective approach to the pyrroloisoquinoline ring system through the application of N-acyliminium chemistry from readily available non-racemic chiral templates. The stereochemical outcome of the cyclisation reactions has been determined by NOE and X-ray crystallography. We also demonstrate the synthetic potential of our new approach through removal of the pendant hydroxymethyl auxiliary from a product of cyclisation.