80582-39-4

Basic information

• Product Name: (S)-3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPAN-1-OL
• Synonyms: (S)-BETA-(3,4-DIMETHOXYPHENYL)ALANINOL;(S)-3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPAN-1-OL;(S)-2-amino-3-(3,4-dimethoxyphenyl)propan-1-ol;REF DUPL: (S)-beta-(3,4-dimethoxyphenyl)alaninol;(S)-b-AMino-3,4-diMethoxybenzenepropanol
• CAS NO: 80582-39-4
• Molecular Formula: C₁₁H₁₇NO₃
• Molecular Weight: 211.26
• Mol File: 80582-39-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPAN-1-OL(80582-39-4)
• EPA Substance Registry System: (S)-3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPAN-1-OL(80582-39-4)

Safety Data

• Hazardous Substances Data: 80582-39-4(Hazardous Substances Data)

Usage

General Description

(S)-3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPAN-1-OL is a chemical compound with the molecular formula C12H19NO3. It is an amino alcohol with a chiral center, meaning it exists in two enantiomeric forms. The compound is a derivative of phenylpropanolamine, a drug with sympathomimetic properties that was once used as a decongestant and appetite suppressant. The chemical structure of (S)-3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPAN-1-OL contains a substituted benzene ring and an amino group attached to a three-carbon chain. It has been studied for its potential pharmacological activities, including its ability to interact with adrenergic receptors and its potential as a drug lead in the development of new therapeutic agents.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 32161-30-1 (S)-3,4-dimethoxyphenylalanine 
• 53053-92-2 N-formyl-3,4-dimethoxy-L-phenylalanine 
• 59-92-7 levodopa 
• 78083-80-4 (S)-2-amino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester 

Downstream Products

• 1042308-66-6 (3S,6aS,9aR)-3-(3,4-dimethoxybenzyl)-octahydro-1-oxa-3a-azacyclopenta[d]inden-4-one 
• 1042308-80-4 C₂₄H₂₉NO₄ 
• 110469-83-5 (R)-2-(3,4-Dimethoxy-phenyl)-5-((R)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-2-isopropyl-pentanenitrile 
• 110469-83-5 (S)-2-(3,4-Dimethoxy-phenyl)-5-((R)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-2-isopropyl-pentanenitrile 
• 112276-31-0 (R)-5-((R)-6,7-Dimethoxy-3,4-dihydro-isoquinolin-3-yl)-2-(3,4-dimethoxy-phenyl)-2-isopropyl-pentanenitrile 
• 112276-31-0 (S)-5-((R)-6,7-Dimethoxy-3,4-dihydro-isoquinolin-3-yl)-2-(3,4-dimethoxy-phenyl)-2-isopropyl-pentanenitrile 
• 112276-36-5 (R)-3-<(R)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhex-1-yl>-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline 
• 105740-32-7 (R)-3-<(S)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhex-1-yl>-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline 
• 105740-26-9 (3R,7R)-7-formamido-3,8-di-(3,4-dimethoxyphenyl)-2-methyl-3-octanenitrile 
• 105740-25-8 (3S,7R)-7-formamido-3,8-di-(3,4-dimethoxyphenyl)-2-methyl-3-octanenitrile 
• 105779-73-5 (2R)-1-(3,4-dimethoxyphenyl)-2-t-butoxycarbonylamino-6-cyano-6-(i-propyl)-6-(3,4-dimethoxyphenyl)hexane 
• 105811-46-9 (S)-2-(tert-butoxycarbonylamino)-3-(3,4-dimethoxyphenyl)-1-(4-methylbenzenesulfonyloxy)propane 
• 112276-40-1 Methanesulfonic acid (R)-4-tert-butoxycarbonylamino-5-(3,4-dimethoxy-phenyl)-pentyl ester 
• 105740-20-3 (R)-6-Amino-2,7-bis-(3,4-dimethoxy-phenyl)-2-isopropyl-heptanenitrile 

Relevant articles and documents

NOVEL INDOLE AND PYRROLOPYRIDINE AMIDES

The present invention relates to indole and pyrrolopyridine amide derivatives of formula (I) wherein R1, R 2, R 3, U, V, W, X, Y, Z and ring A are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.

Facile and highly stereoselective synthesis of the tetracyclic erythrinane core

A highly stereoselective synthesis of the tetracyclic core of the Erythrina alkaloids is reported through the application of a Meyers bicyclic lactam template.

Tetrahydroisoquinoline derivatives

Compounds of the formula STR1 wherein R1 and R2 and each independently --H or lower alkoxy; R3 and R4 are each independently lower alkyl; and R5 and R6 are each --OCH3, or together form --OCH2 O-- or --OCH2 CH2 O--, and pharmaceutically acceptable acid addition salts thereof are prepared by cyclizing, deoxygenating, coupling, or hydrogenating the intermediates disclosed herein.