40625-28-3

Basic information

• Product Name: N-(thiophen-2-ylmethyl)aniline
• Synonyms: N-(thiophen-2-ylmethyl)aniline;N-phenyl-N-(2-thienylmethyl)amine
• CAS NO: 40625-28-3
• Molecular Formula: C₁₁H₁₁NS
• Molecular Weight: 189.27674
• Mol File: 40625-28-3.mol
• Article Data: 41

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(thiophen-2-ylmethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(thiophen-2-ylmethyl)aniline(40625-28-3)
• EPA Substance Registry System: N-(thiophen-2-ylmethyl)aniline(40625-28-3)

Safety Data

• Hazardous Substances Data: 40625-28-3(Hazardous Substances Data)

Upstream product

• 765-50-4 2-Chloromethylthiophene 
• 62-53-3 aniline 
• 98-03-3 thiophene-2-carbaldehyde 
• 5918-68-3 (E)-N-phenyl-1-(thiophen-2-yl)methanimine 
• 636-72-6 2-thiophenemethanol 
• 1527-91-9 N-phenylbenzamidine 
• 98-95-3 nitrobenzene 
• 6846-13-5 N-phenyl-2-thiophenecarboxamide 
• 5918-68-3 N-thiophen-2-ylmethyleneaniline 
• 81994-43-6 2-(phenylamino)-2-(thiophen-2-yl)acetonitrile 
• 1918-82-7 2-vinylthiophene 
• 473929-75-8 phenyl-thiophen-2-ylmethyl-triethylsilanyl-amine 
• 51305-92-1 cyclohexyl-thiophen-2-ylmethylene-amine 

Downstream Products

• 101737-90-0 phenyl-[2]thienylmethyl-carbamic acid-(2-diethylamino-ethyl ester) 
• 101785-49-3 phenyl-[2]thienylmethyl-carbamic acid-(2-pyrrolidino-ethyl ester) 
• 860710-35-6 2-dimethylamino-1-(N-[2]thienylmethyl-anilino)-propane 
• 872305-70-9 N-phenyl-N-[2]thienylmethyl-glycin-ethyl ester 
• 117776-22-4 2-Brom-N-(2-thienylmethyl)acetanilid 
• 439908-95-9 1-methyl-3(R)-(phenyl(thiophen-2-ylmethyl)carbamoyloxy)-1-azoniabicyclo[2.2.2]octane bromide 
• 439909-09-8 1-(2-phenoxyethyl)-3-(R)-(phenyl)(thiophen-2-ylmethyl)carbamoyloxy-1-azoniabicyclo[2.2.2]octane bromide 
• 439908-94-8 phenyl(thiophen-2-ylmethyl)carbamic acid 1-azabicyclo[2.2.2]oct-3(R)-yl ester 
• 1312718-58-3 C₁₂H₁₀ClNOS 
• 34243-33-9 2-thiophen-2-yl-quinoline 
• 81994-43-6 2-(phenylamino)-2-(thiophen-2-yl)acetonitrile 
• 1374762-46-5 N-phenyl-N-(thiophen-2-ylmethyl)-2-(m-tolyloxy)acetamide 

Relevant articles and documents

Reactions of cyclometalated carbonyliron complex derived from thienyl Schiff base

Cyclometalated hexacarbonyldiiron complex 2, which derived from N-(2-thienylmethylidene)aniline, undergoes (1) thermolysis to recover the original Schiff base 1, (2) reduction to form a hydrogenation product of the original thienyl Schiff base 3, (3) substitution to form a phosphine-substituted complex 4, and (4) chemical as well as electrochemical oxidation to produce a γ-lactam 5.

Nickel Complexes Bearing N,N,O-Tridentate Salicylaldiminato Ligand: Efficient Catalysts for Imines Formation via Dehydrogenative Coupling of Primary Alcohols with Amines

Treatment of salicylaldiminato ligand L1H-L2H (L1H = 2,4-di-tert-butyl-6-((quinolin-8-ylimino)methyl)phenol; L2H = 2,4-di-tert-butyl-6-(((2-(diethylamino)ethyl)imino)methyl)phenol) with Ni(OAc)2·4H2O in refluxing ethanol afforded nickel complexes [(L1)Ni(OAc)] (1) and [(L2)Ni(OAc)] (2), respectively. Reaction of L3H (L3H = (2,4-di-tert-butyl-6-(((2-(pyridin-2-yl)ethyl)imino)methyl)phenol)) with Ni(OAc)2·4H2O in the presence of excess triethylanmine gave the dual ligands coordinated nickel complex [(L2)2Ni] (3). Complexes 1-3 were well characterized by high-resolution mass spectrometry, infrared spectroscopy, elemental analysis, and X-ray diffraction analysis. All the three Ni(II) complexes exhibited efficient activity and good selectivity in the acceptorless dehydrogenative coupling of alcohols and amines to produce imines and diimines. The present protocol provides an atom-economical and sustainable route for the synthesis of various imine derivatives by employing an earth-abundant nickel salt and easily prepared salicylaldiminato ligands.

HYDROGENATION OF IMINES WITH RU COMPLEXES

The present invention relates to the field of catalytic hydrogenation and to the use of ruthenium complexes in base-free hydrogenation processes for the reduction of imines into the corresponding amines.