40651-88-5 Usage
Classification
Aliphatic amine 2-(ethylamino)propanenitrile is classified as an aliphatic amine due to its open-chain structure and the presence of a nitrogen atom.
Physical state
Clear, colorless liquid at room temperature The compound is in a liquid state under standard conditions, and it is transparent and colorless.
Uses
Organic synthesis, pharmaceuticals, and agrochemicals 2-(ethylamino)propanenitrile is commonly used as a reagent in organic synthesis for the formation of amides and imidates, and it is also used in the manufacturing of pharmaceuticals and agrochemicals.
Hazardous properties
Irritation to skin, eyes, and respiratory system Handling 2-(ethylamino)propanenitrile requires caution, as it can cause irritation to the skin, eyes, and respiratory system if not properly managed.
Check Digit Verification of cas no
The CAS Registry Mumber 40651-88-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,6,5 and 1 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 40651-88:
(7*4)+(6*0)+(5*6)+(4*5)+(3*1)+(2*8)+(1*8)=105
105 % 10 = 5
So 40651-88-5 is a valid CAS Registry Number.
40651-88-5Relevant articles and documents
Photoredox-Catalyzed Cα-H Cyanation of Unactivated Secondary and Tertiary Aliphatic Amines: Late-Stage Functionalization and Mechanistic Studies
Yilmaz, Ozgur,Oderinde, Martins S.,Emmert, Marion H.
, p. 11089 - 11100 (2018/09/12)
This paper describes the development and mechanistic studies of a general, high-yielding amine Cα-H cyanation protocol via photoredox catalysis. Inexpensive NaCN is employed as the cyanide source and air is the external oxidant, resulting in mild and highly functional group tolerant conditions. Notably, efficient Cα-H cyanations of secondary and tertiary aliphatic amines and of complex, biologically active compounds (drugs) can be performed using the established methodology. Mechanistic studies suggest that the carboxylic acid additive has three effects: formation of a stabilizing hemiaminal intermediate, prevention of catalyst decomposition by protonating the substrate, and modulation of fluorescence quenching of the photoexcited catalyst species.
