40662-66-6

Upstream product

• 99-75-2 4-methyl-benzoic acid methyl ester 
• 94-08-6 4-methylbenzoic acid ethyl ester 
• 99-94-5 p-Toluic acid 
• 93-58-3 benzoic acid methyl ester 

Downstream Products

• 57422-80-7 α,α-dideuterio-p-methylbenzyl bromide 
• 13277-99-1 4-methylbenzaldehyde-α-d₁ 
• 104-87-0 4-methyl-benzaldehyde 
• 26204-18-2 <α,α,α-2H3>p-xylene 
• 203579-68-4 2-methyl-5-trideuteriomethyl-1,4-benzoquinone 
• 104-85-8 para-methylbenzonitrile 
• 1454775-18-8 C₁₈H₁₉⁽²⁾HN₂O 
• 32700-74-6 3-isopropyl-2-p-tolyl-3H-quinazolin-4-one 
• 1262758-64-4 N-(deuterio(4-methylphenyl)methylene)-4-methylbenzenesulfonamide 
• 156027-98-4 O-(α,α-dideuterio-p-methylbenzyl) N-acetoxybenzohydroxamate 
• 156028-05-6 O-(α,α-dideuterio-p-methylbenzyl) N-chlorobenzohydroxamate 
• 156028-03-4 α,α-dideuterio-p-methylbenzyl benzohydroxamate 
• 33712-36-6 <α,α-2H2>-4-methylbenzyl chloride 

Relevant academic research and scientific papers

Four-Component Radical Dual Difunctionalization (RDD) of Two Different Alkenes with Aldehydes and tert-Butyl Hydroperoxide (TBHP): An Easy Access to β,δ-Functionalized Ketones

A convenient Fe-catalyzed four-component radical dual difunctionalization and ordered assembly of two alkenes with aromatic/aliphatic aldehydes and TBHP to provide chain elongated β,δ-functionalized ketones via a one-pot procedure has been developed. Alde

Reductive Deuteration of Aromatic Esters for the Synthesis of α,α-Dideuterio Benzyl Alcohols Using D 2O as Deuterium Source

α,α-Dideuterio benzyl alcohols are important building blocks for the synthesis of deuterium-labeled medicines and agrochemicals. We have developed the first general single-electron transfer reductive deuteration of readily commercially available aromatic

An α, α - dideuterium substituted benzyl alcohol compound. Deuterated drug and method for reducing deuteration of benzoate compound

The invention relates to a method. Α, α-deuterated benzyl alcohol compound and preparation thereofΑ, αThe method for reducing and deuteration - dideuterium-substituted benzyl alcohol compounds is characterized in that the benzoate compound represented by

Mechanistic Studies into the Oxidative Addition of Co(I) Complexes: Combining Electroanalytical Techniques with Parameterization

The oxidative addition of organic electrophiles into electrochemically generated Co(I) complexes has been widely utilized as a strategy to produce carbon-centered radicals when cobalt is ligated by a polydentate ligand. Changing to a bidentate ligand prov

Photocatalysis with Quantum Dots and Visible Light: Selective and Efficient Oxidation of Alcohols to Carbonyl Compounds through a Radical Relay Process in Water

Selective oxidation of alcohols to aldehydes/ketones has been achieved with the help of 3-mercaptopropionic acid (MPA)-capped CdSe quantum dot (MPA-CdSe QD) and visible light. Visible-light-prompted electron-transfer reaction initiates the oxidation. The thiyl radical generated from the thiolate anion adsorbed on a CdSe QD plays a key role by abstracting the hydrogen atom from the C?H bond of the alcohol (R1CH(OH)R2). The reaction shows high efficiency, good functional group tolerance, and high site-selectivity in polyhydroxy compounds. The generality and selectivity reported here offer a new opportunity for further applications of QDs in organic transformations.

Redox reaction between benzyl azides and aryl azides: concerted synthesis of aryl nitriles and anilines

A unique and novel reaction between benzyl azides and aryl azides is described to synthesize aryl nitriles and anilines concurrently, which is catalyzed with a photoactivated diruthenium complex. N-Unsubstituted imines (N-H imines) are generated first from benzyl azides, followed by the hydrogen transfer reaction between N-H imines and aryl azides. A wide range of aryl nitriles and anilines were synthesized under neutral and mild reaction conditions.

Isotopic labelling studies for a gold-catalysed skeletal rearrangement of alkynyl aziridines

Isotopic labelling studies were performed to probe a proposed 1,2-aryl shift in the gold-catalysed cycloisomerisation of alkynyl aziridines into 2,4-disubstituted pyrroles. Two isotopomers of the expected skeletal rearrangement product were identified usi

Computational and experimental structure-reactivity relationships: evidence for a side reaction in Alpine-Borane reductions of d-benzaldehydes

Extraordinary stereoselectivity, approaching 100%, has been reported in the reductions of d-benzaldehydes by B-isopinocampheyl-9-borabicyclo[3.3.1]nonane (Alpine-Borane). This is likely because of the extreme size disparity of groups on either side of the carbonyl. Here, we present a structure-reactivity study whereby the reductions of variably substituted d-benzaldehydes are explored using highly sensitive measures for enantiomeric excess and relative reactivity. These results are compared to the relative rates predicted from density functional calculations. The results indicate that 2,6-disubstitution adversely affects the stereoselectivity by means of a non-selective reduction via the dehydroboration product of Alpine-Borane, 9-borabicyclo[3.3.1]nonane.

Decatungstate-mediated radical reactions of C6o with substituted toluenes and anisoles: A new photochemical functionalization strategy for fullerenes

A convenient, highly efficient, decatungstate-mediated chemical methodology to functionalize fullerenes is demonstrated. A variety of radicals have been generated by the photochemical interaction of tetrabutylammonium decatungstate [(n-Bu4N)su

Use of kinetic isotope effects to delineate the role of phenylalanine 87 in P450BM-3

The substrate oxidation rates of P450BM-3 are unparalleled in the cytochrome P450 (CYP) superfamily of enzymes. Furthermore, the bacterial enzyme, originating from Bacillus megaterium, has been used repeatedly as a model to study the metabolism