40673-68-5

Upstream product

• 551-93-9 2-aminoacetophenone 
• 107-07-3 2-chloro-ethanol 
• 117607-26-8 1-<2-(4-morpholinyl)phenyl>ethanone 
• 118-93-4 o-hydroxyacetophenone 
• 141-43-5 ethanolamine 
• 445-27-2 2'-Fluoroacetophenone 

Downstream Products

• 139515-41-6 2-(2-{1-[(4,5-Diphenyl-oxazol-2-yl)-hydrazono]-ethyl}-phenylamino)-ethanol 

Relevant academic research and scientific papers

A process for the preparation method of the compound aromatic amines (by machine translation)

The invention discloses a method for preparing aromatic amine compounds, comprising the following steps: under protection of inert gas, with the ratio of the phenolic compound amine according to mole 1:2 - 40 are mixed and dissolved in the solvent, 50 - 140 °C reaction 6 - 15 hours, corresponding to preparing polymerizable aromatic amine compound, and then after treatment to obtain a pure aromatic amine compound. Raw materials of this invention generally are easy, simple operation, substrate and wide range of application, in the absence of catalyst under catalytic conditions of the phenolic compound can be obtained by nucleophilic addition reaction of the corresponding aromatic amine compound, and is suitable for industrial production. The present invention allows the presence of water in the reaction system, can be ammonia or hydrazine hydrate as the substrate, in order to ammonium chloride as a catalyst and a cosolvent, the success of the preparation to obtain a level from phenol hydroxy aromatic primary amino compound. The invention to phenol hydroxy has better selectivity, even if the presence of halogen atoms in the substrate does not affect the occurrence of the reaction. (by machine translation)

Neighbourgroup Participation with the Dehydrogenation of Cyclic Amines of the o-Substituted Aniline Type

The 2-Aminobenzylalcohols 1a - c produced with mercury-edta dehydrogenation the lactams 6a - c; the pipecoline 2b yielded the benzoxazine 3b indicating the participation of the nucleophilic hydroxymethyl group. The 2-aminobenzaldehydes showed a different behaviour in dependence on the ring size of the amine part: 7a, b led - via intermediate reaction of the hemiaminal 9 with the electrophilic formyl function - to the lactams 11a, b, while 7c gave rise to the aminoaldehyde 12 as major product and similarly the pipecoline 15 to the aminoketone 16. From 2′-(4-morpholinyl)-acetophenone (22) were received the lactam 31 and the aminoethanol 32, both by a twofold dehydrogenation.