117607-26-8Relevant academic research and scientific papers
Ruthenium-catalyzed transfer hydrogenation of amino- and amido-substituted acetophenones
Watson, Andrew J. A.,Fairbanks, Antony J.
supporting information, p. 6784 - 6788 (2013/11/06)
The ruthenium-catalyzed transfer hydrogenation of electron-rich amino-substituted acetophenones is reported. Variation of the reductant, ligands, base, and solvent allowed reaction optimization. A key discovery was the use of 1,4-butanediol as an irreversible reducing agent, which significantly improved the conversion. A range of amino- and amido-substituted aryl ketones were explored, and they all gave the corresponding alcohols in good yield, which demonstrates the wider applicability of this process. The ruthenium-catalyzed reduction of electron-rich amino-substituted acetophenones with 1,4-butanediol as an irreversible reducing agent is reported. Optimization of the conditions and variation of the amino substituent are explored as is the use of amido- and sulfonamidoacetophenones with varying results. Copyright
Unprecedented construction of C=C double bonds via Ir-catalyzed dehydrogenative and dehydrative cross-couplings
Nie, Shao-Zhen,Sun, Xiang,Wei, Wen-Tao,Zhang, Xue-Jing,Yan, Ming,Xiao, Jian-Liang
supporting information, p. 2394 - 2397 (2013/06/27)
Unprecedented constructions of C=C double bonds have been achieved by Ir-catalyzed intramolecular dehydrogenative and dehydrative cross-coupling of tertiary amines and ketones. The reactions are proposed to proceed via an Ir-mediated C-H activation mechan
Cyanoamidine P2X7 antagonists for the treatment of pain
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Page/Page column 20, (2008/06/13)
Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1-R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compounds are particularly useful in the treatment of pain, inflammation and neurodegeneration states.
Neighbourgroup Participation with the Dehydrogenation of Cyclic Amines of the o-Substituted Aniline Type
Moehrle,Mehrens
, p. 1369 - 1378 (2007/10/03)
The 2-Aminobenzylalcohols 1a - c produced with mercury-edta dehydrogenation the lactams 6a - c; the pipecoline 2b yielded the benzoxazine 3b indicating the participation of the nucleophilic hydroxymethyl group. The 2-aminobenzaldehydes showed a different behaviour in dependence on the ring size of the amine part: 7a, b led - via intermediate reaction of the hemiaminal 9 with the electrophilic formyl function - to the lactams 11a, b, while 7c gave rise to the aminoaldehyde 12 as major product and similarly the pipecoline 15 to the aminoketone 16. From 2′-(4-morpholinyl)-acetophenone (22) were received the lactam 31 and the aminoethanol 32, both by a twofold dehydrogenation.
