40686-14-4

Basic information

• Product Name: Benzenesulfonyl chloride, 4-(2,5-dioxo-1-pyrrolidinyl)-
• CAS NO: 40686-14-4
• Molecular Formula: C10H8ClNO4S
• Molecular Weight: 273.697
• Mol File: 40686-14-4.mol

Chemical Properties

• CAS DataBase Reference: Benzenesulfonyl chloride, 4-(2,5-dioxo-1-pyrrolidinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonyl chloride, 4-(2,5-dioxo-1-pyrrolidinyl)-(40686-14-4)
• EPA Substance Registry System: Benzenesulfonyl chloride, 4-(2,5-dioxo-1-pyrrolidinyl)-(40686-14-4)

Safety Data

• Hazardous Substances Data: 40686-14-4(Hazardous Substances Data)

Upstream product

• 102-14-7 N-phenyl-succinamic acid 
• 5694-39-3 N-(4-chlorosulfonyl-phenyl)-succinamic acid 
• 75-36-5 acetyl chloride 
• 83-25-0 N-phenylmaleimide 

Downstream Products

• 40266-14-6 4-succinimido-benzenesulfonic acid-[2]pyridylamide 
• 74105-55-8 C₁₅H₁₉N₃O₆S 
• 40686-17-7 C₁₀H₁₅N₅O₄S 
• 74105-53-6 p-succinimidobenzenesulfonyl hydrazide 
• 1061624-57-4 N'-{3-(R)-[2-(S)-(1H-indol-3-yl)-1-(methylcarbamoyl)-ethylcarbamoyl]-5-methylhexanoyl}-N-(4-succinimidyl)-benzenesulfonylhydrazide 
• 1370006-33-9 1-[4-(2,5-dioxopyrrolidine-1-yl)benzenesulphonyl]-5-oxopyrrolidine-2-carboxylic acid amide 
• 1030617-01-6 1-[4-(2,5-dioxo pyrrolidin-1-yl)benzenesulphonyl]-5-oxopyrrolidin-2-carboxylic acid 
• 1206465-47-5 2-[4-(3-carboxypropionylamino)benzenesulphonylamino]pentanedioic acid 

Relevant articles and documents

Possible antineoplastic agents, part XVII: Synthesis, antitumor and antiangiogenic study of few bioisosteres of thalidomide metabolites

Two series of bioisostere of thalidomide metabolites and their cyclized variants were designed, synthesized and characterized. In vivo antitumor activity was studied on EAC in swiss albino mice. Cytotoxicity study was carried out on HUVEC and Vero cell lines by MTT assay method. Antiangiogenic activity on Ehrlich ascites tumor (EAT) was investigated studying inhibition of formation of micro vessels by identification of CD31 antigen through immunohistochemistry. One molecule has exhibited both antitumor and antiangiogenic activity but there is no significant toxic effect on normal cell.

SYNTHESIS AND REACTIONS OF N-(p-CHLOROSULPHONYLPHENYL)-SUCCINIMIDE, -GLUTARIMIDE AND -CAMPHORIMIDE

N-Phenyl-succinimide, -glutarimide and -camphorimide mreact with chlorosulphonic acid to yield the corresponding sulphonyl chlorides.Condensation with nucleophiles afforded 25 sulphonyl derivatives, which are to be examined for biocidal properties. reacti