406934-67-6

Upstream product

• 20721-07-7 p-(Phenylsulphonyl) benzoic acid hydrazide 
• 75-15-0 carbon disulfide 

Downstream Products

• 1164117-75-2 C₁₉H₁₄N₄O₃S₂ 
• 1164117-73-0 C₂₁H₁₅N₅O₄S₂ 
• 1164117-71-8 C₂₁H₁₆N₄O₂S₂ 
• 1164117-72-9 C₂₂H₁₈N₄O₃S₂ 
• 1164117-74-1 C₂₃H₂₁N₅O₂S₂ 
• 1234015-75-8 C₁₆H₁₄N₄O₄S₂ 
• 1262139-01-4 6-(4-chlorophenyl)-3-[4-(phenylsulfonyl)phenyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1262138-94-2 3-[4-(phenylsulfonyl)phenyl]-6-N-(4-bromophenyl)amino-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1262138-96-4 3-[4-(phenylsulfonyl)phenyl]-6-N-(4-methylphenyl)amino-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1262138-95-3 3-[4-(phenylsulfonyl)phenyl]-6-N-(4-methoxyphenyl)amino-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1262139-04-7 6-(4-aminophenyl)-3-[4-(phenylsulfonyl)phenyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1262139-07-0 6-[(3-bromo-4-chloro)phenyl]-3-[4-(phenylsulfonyl)phenyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1262139-06-9 6-[(3,4,5-trihydroxyphenyl)]-3-[4-(phenylsulfonyl)phenyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1262139-05-8 6-[(4-aminomethyl)phenyl]-3-[4-(phenylsulfonyl)phenyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 

Relevant academic research and scientific papers

Synthesis, characterization and antibacterial activity of some triazole Mannich bases carrying diphenylsulfone moieties

A series of Mannich bases of 4-substituted 5-[4-(4-X-phenylsulfonyl)phenyl]-2,4-dihydro-3H-1,2,4-triazole-3-thiones, X = H, Cl, Br, 3 and 5 were synthesized and characterized on the basis of IR, NMR and elemental analyses. The potential antibacterial effe

[1,2,4]Triazole derivatives as 5-HT1A serotonin receptor ligands

A series of new 4-amino-3-[3-[4-(2-methoxy or nitro phenyl)-1-piperazinyl] propyl]thio]-5-(substitutedphenyl)[1,2,4]triazoles 11a-t was synthesized in order to obtain compounds with high affinity and selectivity for 5-HT1A receptor over the α1-adrenoceptor. A series of isomeric 4-amino-2-[3-[4-(2-methoxy or nitro phenyl)-1-piperazinyl]propyl]-5-(substitutedphenyl)-2,4-dihydro-3H[1,2,4]triazole-3-thiones 12a-r was also isolated and characterized. New compounds were tested to evaluate their affinity for 5-HT1A receptor and α1-adrenoceptor in radioligand binding experiments. As a general trend, triazoles 11a-t showed a preferential affinity for the 5-HT1A receptor whereas isomeric 2,4-dihydro-3H[1,2,4]triazole3-3-thiones 12a-r preferentially bind to the α1-adrenoceptor site. Several molecules showed affinities in the nanomolar range and 4-amino-3-[3-[4-(2-methoxyphenyl)-1-piperazinyl]thio]-5-(4-propyloxy-phenyl)[1,2,4]triazole (11o) was the most selective derivative for the 5-HT1A receptor (Kiα1/Ki5-HT1A=55). The decrease in 5-HT1A=55). The decrease in 5-HT1A = 55). The decrease in 5-HT1A receptor selectivity in 3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]thio]-5-(substitutedphenyl) [1,2,4] triazole 14a-b, lacking in the amino group in 4-position of the triazole ring, in comparison with their analogues in the series 11a-t, suggest that the amino function represents a critical structural feature in derermining 5-HT1A receptor selectivity in this class of compounds. Copyright