406954-91-4

Basic information

• Product Name: N-(2,2-dimethoxyethyl)-N-[2-(2-bromophenyl)ethyl]-2-(cyclohexylcarbonylamino)acetamide
• Synonyms: N-(2,2-dimethoxyethyl)-N-[2-(2-bromophenyl)ethyl]-2-(cyclohexylcarbonylamino)acetamide
• CAS NO: 406954-91-4
• Molecular Weight: 455.392
• Mol File: 406954-91-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2,2-dimethoxyethyl)-N-[2-(2-bromophenyl)ethyl]-2-(cyclohexylcarbonylamino)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,2-dimethoxyethyl)-N-[2-(2-bromophenyl)ethyl]-2-(cyclohexylcarbonylamino)acetamide(406954-91-4)
• EPA Substance Registry System: N-(2,2-dimethoxyethyl)-N-[2-(2-bromophenyl)ethyl]-2-(cyclohexylcarbonylamino)acetamide(406954-91-4)

Safety Data

• Hazardous Substances Data: 406954-91-4(Hazardous Substances Data)

Upstream product

• 98-89-5 Cyclohexanecarboxylic acid 
• 243139-85-7 phenylmethyl 2-(cyclohexylcarbonylamino)acetate 
• 65185-58-2 2-(2-bromophenyl)ethanamine 
• 32377-88-1 (cyclohexanecarbonyl-amino)-acetic acid 
• 406954-90-3 (2,2-dimethoxyethyl)-[2-(2-bromophenyl)ethyl]amine 

Downstream Products

• 55268-74-1 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one 
• 406954-89-0 1-[2-(2-bromophenyl)ethyl]-4-(cyclohexylcarbonyl)-1,3,4-trihydropyrazin-2-one 

Relevant articles and documents

Amino acid derived heterocycles: Lewis acid catalyzed and radical cyclizations from peptide acetals

Bicyclization of peptide acetals via nucleophilic attack of a phenyl group on an endocyclic acyliminium ion 4 was explored as a route to novel amino acid derived heterocycles and peptidomimetic scaffolds. In the presence of protic acid, bridged structures such as 6 are formed readily from phenylalanine derivatives, but the fused-ring analogues 5 could not be obtained in good yield. In contrast, radical cyclization of the bromophenyl dihydropyrazinone 7 provides an effective alternative for the synthesis of 5 (n = 0, 1, 2). Additional versatility in this process was demonstrated by efficient synthesis of a different fused ring system, represented by the antihelmintic praziquantel, 8.