4072-28-0

Upstream product

• 623-12-1 4-chloromethoxybenzene 
• 201230-82-2 carbon monoxide 
• 71-43-2 benzene 
• 85-19-8 (5-chloro-2-hydroxyphenyl)phenylmethanone 
• 77-78-1 dimethyl sulfate 
• 89694-48-4 5-chloro-2-methoxyphenyl boronic acid 
• 98-88-4 benzoyl chloride 
• 3393-96-2 p-nitrobenzanilide 
• 102921-26-6 (1,2-dibromoethyl)benzene 

Downstream Products

• 99484-48-7 (5-chloro-2-methoxyphenyl)(phenyl)methanol 
• 71238-48-7 3-(5-chloro-2-methoxy-phenyl)-3-phenyl-acrylic acid ethyl ester 
• 146470-14-6 C₁₅H₁₅ClN₄O*ClH 
• 98061-83-7 6-chloro-3-methyl-4-phenyl-coumarin 
• 26152-84-1 6-chloro-4-phenyl-2H-chromen-2-one 

Relevant academic research and scientific papers

A palladium-catalyzed C-H functionalization route to ketones: Via the oxidative coupling of arenes with carbon monoxide

We describe the development of a new palladium-catalyzed method to generate ketones via the oxidative coupling of two arenes and CO. This transformation is catalyzed by simple palladium salts, and is postulated to proceed via the conversion of arenes into high energy aroyl triflate electrophiles. Exploiting the latter can also allow the synthesis of unsymmetrical ketones from two different arenes.

Compound, its manufacturing method, and the recording material is used, the chemical reagent for analysis and display material (by machine translation)

[Problem] solvent having excellent solubility in a xanthene dye or its precursor. These compounds are used compound material and manufacturing method, and a chemical reagent for analyzing the display material. General formula [a] 7 raw material or precursor compounds and benzophenone dye represented by reducing condensation of phenol, a compound represented by the general formula 7 of. (Q1, Q2 represents an alkyl, cycloalkyl or aryl; Q5 is H, alkyl, aryl or; Q6 is H, halogen, dialkylamino, TDAPB, alkoxy, alkyl or the like)[Drawing] no (by machine translation)

AROMATIC KETONE SYNTHESIS WITH AMIDE REAGENTS AND RELATED REACTIONS

A method of preparing an aryl carbonyl or aryl thiocarbonyl compound, comprises reacting an N-(nitroaryl)-amide or N-(nitroaryl)-thioamide with an aromatic ring, with a superacid catalyst, to produce the aryl carbonyl or aryl thiocarbonyl compound. The superacid is present in an amount of at most 8 equivalents in proportion to the N-(nitroaryl)-amide or N-(nitroaryl)-thioamide. A method of preparing aryl amide or aryl thioamide, comprises reacting an N-(nitroaryl)-carbamide or N-(nitroaryl)-thiocarbamide with an aromatic ring, with a superacid catalyst, to produce the aryl amide or aryl thioamide.

Friedel-crafts acylation with amides

Friedel-Crafts acylation has been known since the 1870s, and it is an important organic synthetic reaction leading to aromatic ketone products. Friedel-Crafts acylation is usually performed with carboxylic acid chlorides or anhydrides, while amides are generally not useful substrates in these reactions. Despite being the least reactive carboxylic acid derivative, we have found a series of amides capable of providing aromatic ketones in good yields (55-96%, 17 examples). We propose a mechanism involving diminished C-N resonance through superelectrophilic activation and subsequent cleavage to acyl cations.

Gold(I)-catalyzed oxidative cleavage of a C-C double bond in water

Oxidative cleavage of the C=C bond to afford ketone or aldehyde products with tert-butyl hydrogenperoxide (TBHP) as the oxidant can be catalyzed by AuCl with neocuproine (1) in water.

ACYLATION OF CHLOROANISOLES

In the reaction of 2-, 3-, and 4-chloroanisoles with the chlorides and anhydrides of acetic, propionic, and 4-substituted benzoic acids in the presence of 1E-3 mole of ferric chloride 35-80percent of the ketone fraction was obtained.Under the reaction con