40733-88-8Relevant academic research and scientific papers
Metal-Free and User-Friendly Regioselective Hydroxyfluorination of Olefins
Sedgwick, Daniel M.,López, Inés,Román, Raquel,Kobayashi, Nanako,Okoromoba, Otome E.,Xu, Bo,Hammond, Gerald B.,Barrio, Pablo,Fustero, Santos
, p. 2338 - 2341 (2018)
A simple, user-friendly, metal-free protocol for the regioselective anti-Markovnikov hydrofluorination of olefins using readily available and inexpensive reagents has been developed. This new approach displays a broader scope than previously reported methodologies and has been applied to the late-stage fluorination of a complex molecule, giving rise to a fluorosteroid derivative. The stereochemistry of the process has also been studied in some detail.
