40736-25-2

Upstream product

• 288-32-4 1H-imidazole 
• 814-68-6 acryloyl chloride 
• 79-10-7 acrylic acid 
• 292638-85-8 acrylic acid methyl ester 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 503565-88-6 (1R)-(4-methylphenylsulfinyl)-3-buten-2-one 
• 936563-87-0 ibrutinib 
• 120671-13-8 1-Benzyl-5-oxo-1,2,3,5,6,7-hexahydro-imidazo[1,2-a]pyridine-8-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Method for catalytically synthesizing acrylamide compound by MOFs-derived zirconium-based ternary oxide solid acid

The invention provides a catalytic synthesis of acrylamide compounds with zirconium-based ternary oxide solid acid as a catalyst, and the low-temperature activity is good. In the synthesis process, the acid is small, the reaction conditions are mild and controllable, the byproducts are few, the reaction yield is effectively improved, the purity is high, the quality is good, and the method is suitable for large-scale production.

Ibrutinib synthesis method

The invention provides an ibrutinib synthesis method and belongs to the field of medicine synthesis. The synthesis method includes the step that a compound M and a compound of formula I undergo acylation reaction in the presence of alkaline. The synthesis method is mild in reaction conditions, side reaction is less, obtained ibrutinib is high in yield, and the purity is 99.50 or above. A syntheticroute of the synthesis method is described as follows.

Aza-Michael addition of aliphatic or aromatic amines to α,β-unsaturated compounds catalyzed by a DBU-derived ionic liquid under solvent-free conditions

A task-specific ionic liquid, 1,8-diazabicyclo[5.4.0]-undec-7-en-8-ium acetate has been successfully used as a catalyst for aza-conjugate addition of aliphatic or aromatic amines to various electron deficient alkenes under solvent-free conditions and at room temperature. The catalyst can be reused for six times without noticeable loss of activity.

The sulfinyl moiety as an intramolecular nucleophile. Part 3: Synthesis of (-)-muricatacin

A short, efficient and highly stereoselective synthesis of (-)-(R,R)-muricatacin is reported. The key steps include a highly diastereoselective reduction of a β-ketosulfoxide to a β-hydroxy sulfoxide, regio- and stereoselective bromohydration of an olefin

ANNULATION OF IMIDAZOLINES: SYNTHESIS OF IMIDAZOPYRIDONES

The enaminoester 1-benzyl-2-(ethoxycarbonylmethylene)-imidazolidine undergoes N-acylation and conjugate C-addition with α,β-unsaturated acyl imidazolides to afford imidazopyridones.

ANOMALIES DANS L'ESTERIFICATION D'ACIDES ETHYLENIQUINONES PAR LA METHODE AU N,N'-CARBONYLIMIDAZOLE

The reaction of N,N'-carbonyldiimidazole with but-3 enoic acid did not lead to the expected azolide; its rearrangement into conjugated isomer was followed by imidazole addition the double bound.These two reaction make inefficient this preparative method for esters and peresters of alkyl substitued α,β-ethylenic acids and β,γ-ethylenic acids without substituent on the α-carbon.