4074-50-4

Upstream product

• 699-83-2 2,6-dihydroxylacetophenone 
• 98954-40-6 2-ethyl-3-methoxyphenol 
• 18610-90-7 1,3-dimethoxy-2-ethylbenzene 
• 92315-54-3 6-acetoxy-6-ethyl-cyclohexa-2,4-dienone 
• 2040-04-2 2,6-dimethoxyacetophenone 
• 2150-47-2 methyl 2,4-dihydroxybenzoate 
• 123501-23-5 4-ethoxy-3-ethyl-2-hydroxy-benzoic acid methyl ester 
• 5653-62-3 2,3-dimethoxybenzonitrile 
• 114274-16-7 2-ethyl-3-methyloxyaniline 
• 102236-67-9 2-ethyl-3-methoxy-benzonitrile 
• 135329-23-6 2-ethyl-3-methoxy-benzoic acid amide 
• 90-00-6 o-Hydroxyethylbenzene 

Downstream Products

• 54473-07-3 3-ethyl-2,4-dihydroxybenzaldehyde 
• 577-54-8 1-(3-ethyl-2,4-dihydroxy-phenyl)-2,2,2-trifluoro-ethanone 
• 91497-63-1 1,3-diacetoxy-2-ethyl-benzene 
• 111224-13-6 1-(3-ethyl-2,4-dihydroxy-phenyl)-ethanone 
• 136498-55-0 α-(1,4-benzodioxan-6-yl)-2,4-dihydroxy-5-ethylacetophenone 
• 136523-94-9 α-(1,4-benzodioxan-6-yl)-2-hydroxy-4-methoxy-5-ethylacetophenone 
• 412018-53-2 2-ethyl-4-methyl-resorcinol 
• 722504-27-0 3-ethyl-2-hydroxy-4-methoxy-benzaldehyde 
• 189831-72-9 3-ethyl-2,4-dimethoxy-benzaldehyde 
• 408330-87-0 3-ethyl-5-chloromethyl-2,4-dimethoxy-benzaldehyde 
• 408336-03-8 5-ethyl-4,6-dimethoxy-isophthalaldehyde 

Relevant academic research and scientific papers

Vases and kites as cavitands

The syntheses, characterizations, and substituent effects on the vase vs kite conformations of 1-17 are described. These compounds are assembled by two-step syntheses from resorcinol (or 2-substituted derivatives) and aldehydes to form octols 18-26 in hig

Synthesis of Fluorescent Probes Targeting Tumor-Suppressor Protein FHIT and Identification of Apoptosis-Inducing FHIT Inhibitors

For the early diagnosis of cancer, leading to a better chance of full recovery, marker genes whose expression is already altered in precancerous lesions are desirable, and the tumor-suppressor gene FHIT is one candidate. The gene product, FHIT protein, has a unique dinucleoside triphosphate hydrolase (AP3Aase) activity, and in this study, we designed and synthesized a series of FHIT fluorescent probes utilizing this activity. We optimized the probe structure for high and specific reactivity with FHIT and applied the optimized probe in a screening assay for FHIT inhibitors. Screening of a compound library with this assay identified several hits. Structural development of a hit compound afforded potent FHIT inhibitors. These inhibitors induce apoptosis in FHIT-expressing cancers via caspase activation. Our results support the idea that FHIT binders, no matter whether inhibitors or agonists of AP3Aase activity, might be promising anticancer agents.

Kolbe-Schmitt type reaction under ambient conditions mediated by an organic base

The combined use of an organic base for resorcinols realized a Kolbe-Schmitt type reaction under ambient conditions. When resorcinols (3-hydroxyphenol derivatives) were treated with DBU under a carbon dioxide atmosphere, nucleophilic addition to carbon dioxide proceeded to afford the corresponding salicylic acid derivatives in high yields.

BORON-CONTAINING SMALL MOLECULES

This invention provides novel compounds of the following formula and pharmaceutical compositions containing such compounds.

QUINAZOLINE COMPOUNDS

The present invention relates to quinazoline compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: (Formula (I)) wherein X, R1, R2, R3, R4, R5, R6 and R7 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

1 -HYDROXY-BENZOOXABOROLES AS ANTIPARASITIC AGENTS

Provided are compounds useful for controlling endoparasites both in animals and agriculture. Further provided are methods for controlling endoparasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling endoparasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. The claimed compounds are described by the following Markush formula:A typical example for a compound according to above formula is: A typical example for a compound according to above formula is:

The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity

(Chemical Equation Presented) Novobiocin, a known DNA gyrase inhibitor, binds to a nucleotide-binding site located on the Hsp90 C-terminus and induces degradation of Hsp90-dependent client proteins at ～700 μM in breast cancer cells (SKBr3). Although many analogues of novobiocin have been synthesized, it was only recently demonstrated that monomeric species exhibit antiproliferative activity against various cancer cell lines. To further refine the essential elements of the coumarin core, a series of modified coumarin derivatives was synthesized and evaluated to elucidate structure-activity relationships for novobiocin as an anticancer agent. Results obtained from these studies have produced novobiocin analogues that manifest low micromolar activity against several cancer cell lines.

DEOXYGENATION OF ALDEHYDES AND KETONES WITH SODIUM CYANOBOROHYDRIDE

Treatment of hydroxy-substituted aromatic aldehydes and ketones with sodium cyanoborohydride yields the corresponding methylene compounds under conditions which favor intermediate carbonium ion formation.

Process for the preparation of resorcinol derivatives

2-Substituted-4,6-di-t-butylresorcinol represented by the general formula: STR1 wherein R represents a straight or branched alkyl group having 1 to 20 carbon atoms, a straight or branched alkenyl group having 2 to 20 carbon atoms and at least one double bond, or an aralkyl group, but the tertiary carbon atom of R is free from direct bonding to the benzene nucleus, is prepared by allowing 4,6-di-t-butylresorcinol to react with a halogen compound represented by the general formula: wherein R has the same meaning as defined above, and X represents a halogen atom, excluding the X bonded to the tertiary carbon of R, in an aqueous alkali solution. By further debutylization of the 2-substituted-4,6-t-butylresorcinol, 2-substituted resorcinol represented by the general formula: STR2 wherein R has the same meaning as defined above, but the tertiary carbon of R is free from direct bonding to the benzene nucleus, is prepared.