136498-55-0Relevant academic research and scientific papers
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors
Cheung, Kwai-Ming J.,Matthews, Thomas P.,James, Karen,Rowlands, Martin G.,Boxall, Katherine J.,Sharp, Swee Y.,Maloney, Alison,Roe, S. Mark,Prodromou, Chrisostomos,Pearl, Laurence H.,Aherne, G. Wynne,McDonald, Edward,Workman, Paul
, p. 3338 - 3343 (2007/10/03)
High-throughput screening identified the 3,4-diarylpyrazole CCT018159 as a novel and potent (7.1 μM) inhibitor of Hsp90 ATPase activity. Here, we describe the synthesis of CCT018159 and a number of close analogues together with data on their biochemical p
SYNTHETIC AND MODIFIED ISOFLAVONOIDS. III. SYNTHESIS OF BENZODIOXANE ANALOGUES OF PSEUDOBAPTIGENIN
Aitmambetov, A.,Grishko, L. G.,Khilya, V. P.
, p. 720 - 725 (2007/10/02)
Benzodioxane analogues of pseudobaptigenin with alkyl fragments in positions 2 and 6 of the chromone ring have been synthesized from α-(1,4-benzodioxan-6-yl)-2-hydroxy-6-alkylacetophenones.
PMR SPECTRA AND CONFORMATIONS OF BENZODIOXANE AND BENZODIOXEPAN DERIVATIVES OF FLAVANONE AND ISOFLAVANONE
Khilya, V.P.,Litkei, D.,Kovtun, E.N.,Al'Budi, Kh.,Kornilov, M.Yu.,Turov, A.V.
, p. 595 - 603 (2007/10/02)
PMR spectra were obtained for benzodioxane and benzodioxepan derivatives of chromanone.The heterocyclic substituent in 2-substituted chromanones (flavanone analogs) has equatorial orientation, while the heterocyclic substituent in 3-substituted chromanones (isoflavanone analogs) has axial orientation.These conclusions are based on analysis of the coupling constans, aromatic solvent-induced shifts, and shifts induced by lanthanide shift reagents.
