4074-53-7

Upstream product

• 3019-20-3 isopropylthiobenzene 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 4253-89-8 diisopropyl sulfide 
• 99-90-1 para-bromoacetophenone 
• 20607-43-6 sodium isopropanethiolate 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 4688-34-0 1,2-dimorpholin-4-ylethane-1,2-dithione 
• 129602-89-7 (4-(2-propylthio)phenyl)acetothiomorpholide 
• 129602-90-0 2-(4-(2-propylthio)phenyl)2-oxoacetothiomorpholide 
• 99858-88-5 4-(2-propylthio)acetophenone oxime 
• 70080-58-9 (4-Isopropylsulfanyl-phenyl)-oxo-acetic acid 
• 15560-17-5 ethyl 2-(4-(isopropylthio)phenyl)acetate 
• 3583-60-6 2-(4-(isopropylthio)phenyl)acetic acid 
• 129602-94-4 (4-(2-propylthio)phenyl)acetamide 
• 129602-87-5 O-(2-aminoethyl)-4-(2-propylthio)acetophenone oxime 
• 129602-88-6 O-(3-dimethylaminopropyl)-4-(2-propylthio)acetophenone oxime 
• 15561-02-1 N-Hydroxy-2-(4-isopropylsulfanyl-phenyl)-acetamide 

Relevant academic research and scientific papers

PYRAZOLONE DERIVATIVES AS NITROXYL DONORS

The disclosed subject matter provides pyrazolone derivative compounds, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

Alkyl- and arylthiolation of aryl halides catalyzed by fluorinated bis-imino-nickel NNN pincer complexes [NiCl2{C5H 3N-2,6-(CHNArf)2}]

The synthesis of bis-imino nickel(II) NNN pincer complexes of the type [NiCl2{C5H3N-2,6-(CHNArf) 2}]; Arf= C6H3-2,3-F2 (1), C6H3-2,5-F2 (2), C6H 3-3,4-F2 (3), C6H3-3,5-F2 (4), C6H2-2,3,4-F3 (5), C6H 2-2,3,6-F3 (6), C6H2-2,4,5-F 3 (7), C6H2-2,4,6-F3 (8), has been achieved and their reactivity in alkyl- and arylthiolation reactions of halobenzenes examined. The use of fluorinated substituents Arf on the imines has allowed the tuning of the electronics in these complexes and the influence of these substituents and those of the disulfides in the thiolation reactions have been analyzed.

POTENTIAL ANTIDEPRESSANT AND ANTI-INFLAMMATORY AGENTS: 4-(2-PROPYLTHIO)ACETOPHENONE OXIMES AND 4-(2-PROPYLTHIO)PHENYLALKANOIC ACIDS

4-(2-Propylthio)acetophenone oxime (IV) was reacted with 2-aminoethyl chloride and 3-dimethylaminopropyl chloride to give the O-(aminoalkyl)oximes V and VI which are analogues of the antidepressant agent fluvoxamine (I).Kindler-Willgerodt reaction of 4-(2

Indene compounds

The invention provides an indene compound represented by the following general formula (I): STR1 wherein R1 means a lower alkyl group, R2 and R3 denote a lower alkyl group individually or an alkylenedioxy group in combination, and R4 and R5 mean individually a substituted or unsubstituted lower alkyl or aryl group or in combination a substituted or unsubstituted piperidino, piperazinyl or homopiperazinyl group together with the adjacent nitrogen atom, with a proviso that not both R4 and R5 are a methyl group at the same time.