4074-63-9

Basic information

• Product Name: 1-[4-(1,1-DIMETHYLETHOXY)PHENYL]-ETHANONE
• Synonyms: 1-[4-(1,1-DIMETHYLETHOXY)PHENYL]-ETHANONE;ETHANONE, 1-[4-(1,1-DIMETHYLETHOXY)PHENYL]-;UKRORGSYN-BB BBV-246918
• CAS NO: 4074-63-9
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.25
• Mol File: 4074-63-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-[4-(1,1-DIMETHYLETHOXY)PHENYL]-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(1,1-DIMETHYLETHOXY)PHENYL]-ETHANONE(4074-63-9)
• EPA Substance Registry System: 1-[4-(1,1-DIMETHYLETHOXY)PHENYL]-ETHANONE(4074-63-9)

Safety Data

• Hazardous Substances Data: 4074-63-9(Hazardous Substances Data)

Usage

General Description

1-[4-(1,1-Dimethylethoxy)phenyl]-ethanone is a chemical compound with the molecular formula C12H16O2. It is also known as PMPA and is used in the pharmaceutical industry as an inhibitor of the enzyme renin. Renin is responsible for the conversion of angiotensinogen to angiotensin I, which is a key step in the regulation of blood pressure and fluid balance. By inhibiting renin, PMPA can help to lower blood pressure and potentially treat conditions such as hypertension and heart failure. 1-[4-(1,1-DIMETHYLETHOXY)PHENYL]-ETHANONE is a white solid that is sparingly soluble in water and is typically used in its crystalline form for research and pharmaceutical purposes.

Upstream product

• 865-47-4 potassium tert-butylate 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 99-90-1 para-bromoacetophenone 
• 115-11-7 isobutene 
• 99-93-4 4-Hydroxyacetophenone 
• 95418-58-9 4-tert-butoxystyrene 

Downstream Products

• 143589-82-6 1(R,S)-(p-tert-butoxyphenyl)ethylamine 
• 653598-48-2 (S)-2-azido-1-(4-tert-butoxy)phenylethanol 
• 653598-47-1 (S)-2-bromo-1-(4-tert-butoxy)phenylethanol 
• 653598-49-3 (S)-1-(2-azido-1-methoxy)ethyl-4-tert-butoxybenzene 
• 653598-50-6 (S)-1-(2-amino-1-methoxy)ethyl-4-tert-butoxybenzene 
• 653598-46-0 2'-bromo-4-tert-butoxyacetophenone 
• 1194065-42-3 5-(1-(4-(tert-butoxy)phenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 

Relevant articles and documents

Catalytic Aerobic Oxidation of Alkenes with Ferric Boroperoxo Porphyrin Complex; Reduction of Oxygen by Iron Porphyrin

We herein describe the development of a mild and selective catalytic aerobic oxidation process of olefins. This catalytic aerobic oxidation reaction was designed based on experimental and spectroscopic evidence assessing the reduction of atmospheric oxygen using a ferric porphyrin complex and pinacolborane to form a ferric boroperoxo porphyrin complex as an oxidizing species. The ferric boroperoxo porphyrin complex can be utilized as an in-situ generated intermediate in the catalytic aerobic oxidation of alkenes under ambient conditions to form oxidation products that differ from those obtained using previously reported ferric porphyrin catalysis. Moreover, the mild reaction conditions allow chemoselective oxidation to be achieved.

Cationic palladium(II) complexes as catalysts for the oxidation of terminal olefins to methyl ketones using hydrogen peroxide

Ligated Pd(II) complexes have been studied for the catalytic oxidation of terminal olefins to their corresponding methyl ketones. The method uses aqueous hydrogen peroxide as the terminal oxidant; a sustainable and readily accessible oxidant. The choice of ligand, counterion and solvent all have a significant effect on catalytic performance and we were able to develop systems which perform well for these challenging oxidations.

Synthesis, stereochemistry confirmation and biological activity evaluation of a constituent from Isodon excisus

A synthesis and stereochemistry confirmation of a constituent recently isolated from the whole plant Isodon excisus is reported. An enantioselective catalytic boron-mediated reduction of an α-bromoketone was utilized in the key synthetic transformation. The methodology described herein was also used for the synthesis of the natural product's enantiomer and several derivatives. In addition, the compounds were evaluated for inhibitory activity in a caspase induction assay. The natural product was found to be devoid of activity, but several derivatives had moderate inhibitory activity (EC 501 μM).