40750-59-2

Basic information

• Product Name: 3,4-DICHLORO-N-METHYLANILINE
• Synonyms: BUTTPARK 62\04-19;3,4-DICHLORO-N-METHYLANILINE;N1-METHYL-3,4-DICHLOROANILINE;N-Methyl-3,4-dichloroaniline;N1-Methyl-3,4-dichloroaniline, 95+%;n-(3,4-dichlorophenyl)-n-methylamine;3,4-Dichloro-N-methylaniline ,97%;3,4-dichloro-N-(2-isopropyl-5-methylcyclohexyl)aniline
• CAS NO: 40750-59-2
• Molecular Formula: C₇H₇Cl₂N
• Molecular Weight: 176.04
• EINECS: -0
• Product Categories: Amines;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het;C7;Nitrogen Compounds
• Mol File: 40750-59-2.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 150-152 °C15 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.3794 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00241mmHg at 25°C
• Refractive Index: n20/D 1.6015(lit.)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.36±0.25(Predicted)
• BRN: 2962410
• CAS DataBase Reference: 3,4-DICHLORO-N-METHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DICHLORO-N-METHYLANILINE(40750-59-2)
• EPA Substance Registry System: 3,4-DICHLORO-N-METHYLANILINE(40750-59-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 2810
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 40750-59-2(Hazardous Substances Data)

Usage

Description

3,4-Dichloro-N-methylaniline, also known as dichloroaniline, is a chemical compound characterized by the molecular formula C7H7Cl2N. It is a pale yellow solid that serves as an important intermediate in the synthesis of various dyes, pigments, pharmaceuticals, and pesticides. However, due to its toxic nature, exposure to this chemical can cause irritation to the skin, eyes, and respiratory system, necessitating careful handling and storage with adherence to proper safety measures.

Uses

Used in Dye and Pigment Industry:
3,4-Dichloro-N-methylaniline is used as a chemical intermediate for the production of various dyes and pigments. Its unique chemical structure allows for the creation of a wide range of colorants used in different applications, including textiles, plastics, and printing inks.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 3,4-Dichloro-N-methylaniline is utilized as a key component in the synthesis of certain drugs. Its aromatic amine structure plays a crucial role in the development of medicinal compounds, contributing to their therapeutic properties.
Used in Pesticide Industry:
3,4-Dichloro-N-methylaniline is also employed in the manufacturing of pesticides. Its chemical properties enable it to act as an effective agent against various pests, helping to protect crops and maintain agricultural productivity.

InChI:InChI=1/C7H7Cl2N/c1-10-5-2-3-6(8)7(9)4-5/h2-4,10H,1H3

Upstream product

• 67-56-1 methanol 
• 95-76-1 m,p-dichloroaniline 
• 68-12-2 N,N-dimethyl-formamide 
• 58566-66-8 3,4-dichloro-N,N-dimethylaniline 
• 50-00-0 formaldehyd 
• 25217-40-7 (3,4-dichlorophenyl)carbamic acid tert-butyl ester 
• 74-88-4 methyl iodide 
• 5470-15-5 N-(3,4-dichlorophenyl)formamide 
• 88010-39-3 2-(N-Methyl-3,4-dichloranilino)-2-phenylacetonitril 
• 88010-41-7 2-(N-Methyl-3,4-dichloranilino)-2-methyl-2-phenylacetonitril 

Downstream Products

• 105942-47-0 3',4'-dichloro-N-methylacetoacetoanilide 
• 1227095-53-5 2-bromoethyl N-(3,4-dichlorobenzyl)sulfamoylcarbamate 
• 74474-02-5 N-(3,4-dichlorophenyl)-N-methyl-N',N'-diethyl-ethylene diamine 
• 67103-26-8 (3,4-Dichloro-phenyl)-methyl-carbamic acid 3-prop-2-ynyloxycarbonylamino-phenyl ester 
• 64797-66-6 3-[1-(3-Bromo-phenyl)-1-methyl-ethyl]-1-(3,4-dichloro-phenyl)-1-methyl-urea 

Relevant articles and documents

Method for realizing N-alkylation by using alcohols as carbon source under photocatalysis

The invention discloses a method for realizing N-alkylation by using alcohols as a carbon source under photocatalysis, and belongs to the technical field of catalytic synthesis. Alcohol, a substrate raw material and a catalyst are placed in a reaction device, ultraviolet and/or visible light irradiation is carried out in an inert atmosphere, after the irradiation is finished, solid-liquid separation is carried out to remove the catalyst, and an N-alkylation product can be obtained through extraction, distillation and purification, wherein the substrate raw material comprises any one of an amine compound, an aromatic nitro compound or an aromatic nitrile compound, the alcohol comprises any one or more of soluble primary alcohols, and the catalyst is metal oxide/titanium dioxide or metal sulfide/titanium dioxide. The method is simple and easy to operate, can be used for efficient photocatalysis one-pot multi-step hydrogenation N-alkylation reaction, and is mild in reaction condition, high in chemical selectivity of N-alkylamine, good in catalyst stability and easy to recycle.

Highly Efficient Binuclear Copper-catalyzed Oxidation of N,N-Dimethylanilines with O2

A binuclear copper-salicylate complex, [Cu(Sal)2(NCMe)]2 (Sal=salicylate), was found to be an active catalyst for the oxidation of N,N-dimethylanilines by O2, affording the corresponding N-methyl-N-phenylformamides as major products. The reactions were carried out with a O2 balloon and the S/C (substrate/catalyst ratio) of the model reaction could be up to 1×105, providing a practical and highly efficient catalytic protocol for accessing N-methyl-N-phenylformamides.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.