40750-59-2

Usage

Uses

Used in Dye and Pigment Industry:
3,4-Dichloro-N-methylaniline is used as a chemical intermediate for the production of various dyes and pigments. Its unique chemical structure allows for the creation of a wide range of colorants used in different applications, including textiles, plastics, and printing inks.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 3,4-Dichloro-N-methylaniline is utilized as a key component in the synthesis of certain drugs. Its aromatic amine structure plays a crucial role in the development of medicinal compounds, contributing to their therapeutic properties.
Used in Pesticide Industry:
3,4-Dichloro-N-methylaniline is also employed in the manufacturing of pesticides. Its chemical properties enable it to act as an effective agent against various pests, helping to protect crops and maintain agricultural productivity.

InChI:InChI=1/C7H7Cl2N/c1-10-5-2-3-6(8)7(9)4-5/h2-4,10H,1H3

Upstream product

• 88010-39-3 2-(N-Methyl-3,4-dichloranilino)-2-phenylacetonitril 
• 95-76-1 m,p-dichloroaniline 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 68-12-2 N,N-dimethyl-formamide 
• 58566-66-8 3,4-dichloro-N,N-dimethylaniline 
• 50-00-0 formaldehyd 
• 25217-40-7 (3,4-dichlorophenyl)carbamic acid tert-butyl ester 
• 5470-15-5 N-(3,4-dichlorophenyl)formamide 
• 88010-41-7 2-(N-Methyl-3,4-dichloranilino)-2-methyl-2-phenylacetonitril 

Downstream Products

• 101264-02-2 N-butyl-N'-(3,4-dichloro-phenyl)-N,N'-dimethyl-urea 
• 13680-69-8 N-methyl-N-(3,4-dichlorophenyl)carbamoyl chloride 
• 61439-32-5 1-(3,4-Dichloro-phenyl)-3-(2,3-dichloro-propionyl)-1-methyl-urea 
• 61439-25-6 3-(2,3-Dibromo-propionyl)-1-(3,4-dichloro-phenyl)-1-methyl-urea 
• 31889-94-8 N-{2,2,2-Trichloro-1-[(3,4-dichloro-phenyl)-methyl-amino]-ethyl}-benzamide 
• 64797-66-6 3-[1-(3-Bromo-phenyl)-1-methyl-ethyl]-1-(3,4-dichloro-phenyl)-1-methyl-urea 
• 67103-26-8 (3,4-Dichloro-phenyl)-methyl-carbamic acid 3-prop-2-ynyloxycarbonylamino-phenyl ester 
• 105942-47-0 3',4'-dichloro-N-methylacetoacetoanilide 
• 74474-02-5 N-(3,4-dichlorophenyl)-N-methyl-N',N'-diethyl-ethylene diamine 

Relevant academic research and scientific papers

Method for realizing N-alkylation by using alcohols as carbon source under photocatalysis

The invention discloses a method for realizing N-alkylation by using alcohols as a carbon source under photocatalysis, and belongs to the technical field of catalytic synthesis. Alcohol, a substrate raw material and a catalyst are placed in a reaction device, ultraviolet and/or visible light irradiation is carried out in an inert atmosphere, after the irradiation is finished, solid-liquid separation is carried out to remove the catalyst, and an N-alkylation product can be obtained through extraction, distillation and purification, wherein the substrate raw material comprises any one of an amine compound, an aromatic nitro compound or an aromatic nitrile compound, the alcohol comprises any one or more of soluble primary alcohols, and the catalyst is metal oxide/titanium dioxide or metal sulfide/titanium dioxide. The method is simple and easy to operate, can be used for efficient photocatalysis one-pot multi-step hydrogenation N-alkylation reaction, and is mild in reaction condition, high in chemical selectivity of N-alkylamine, good in catalyst stability and easy to recycle.

Selective N -monomethylation of primary anilines with the controllable installation of N -CH2D, N -CHD2, and N -CD3units

The selective N-monomethylation of primary anilines was realized by the use of the Me3N-BH3/N,N-dimethylformamide (DMF) system as the methyl source. This method also allows for the controllable introduction of N-CH2D, N-CHD2, and N-CD3 units with high lev

Highly Efficient Binuclear Copper-catalyzed Oxidation of N,N-Dimethylanilines with O2

A binuclear copper-salicylate complex, [Cu(Sal)2(NCMe)]2 (Sal=salicylate), was found to be an active catalyst for the oxidation of N,N-dimethylanilines by O2, affording the corresponding N-methyl-N-phenylformamides as major products. The reactions were carried out with a O2 balloon and the S/C (substrate/catalyst ratio) of the model reaction could be up to 1×105, providing a practical and highly efficient catalytic protocol for accessing N-methyl-N-phenylformamides.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

Binding Mode Characterization and Early in Vivo Evaluation of Fragment-Like Thiols as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa

The increasing emergence of antibiotic resistance necessitates the development of anti-infectives with novel modes of action. Targeting bacterial virulence is considered a promising approach to develop novel antibiotics with reduced selection pressure. The extracellular collagenase elastase (LasB) plays a pivotal role in the infection process of Pseudomonas aeruginosa and therefore represents an attractive antivirulence target. Mercaptoacetamide-based thiols have been reported to inhibit LasB as well as collagenases from clostridia and bacillus species. The present work provides an insight into the structure-activity relationship (SAR) of these fragment-like LasB inhibitors, demonstrating an inverse activity profile compared to similar inhibitors of clostridial collagenase H (ColH). An X-ray cocrystal structure is presented, revealing distinct binding of two compounds to the active site of LasB, which unexpectedly maintains an open conformation. We further demonstrate in vivo efficacy in a Galleria mellonella infection model and high selectivity of the LasB inhibitors toward human matrix metalloproteinases (MMPs).

Evaluation of 4-phenylamino-substituted naphthalene-1,2-diones as tubulin polymerization inhibitors

A series of 4-phenylamino-substituted naphthalene-1,2-dione derivatives were prepared and evaluated as effective antiproliferative agents. MTT assays showed that the compounds with a methyl group on the nitrogen linker exhibited potent antiproliferative activities against human cancer cells. The mechanistic study revealed that these compounds could induce mitochondrial depolarization, which resulted in intracellular ROS production, and they also acted as tubulin polymerization inhibitors. Moreover, the typical compound could arrest A549 cells in the G2/M phase, resulting in cellular apoptosis and induced mitotic arrest in A549 cells through disrupting microtubule dynamics.

Water Soluble Haloanilide Calcium-Release Calcium Channel Inhibitory Compounds and Methods to Control Bone Erosion and Inflammation Associated with Arthritides

A compound that is selected from the group consisting of 3-(3,4-dichloroanilino)-3-oxopropanoic acid (hereinafter “DCOPA”); N-methyl-DCOPA; N,2-dimethyl-DCOPA; 2-methyl-DCOPA; isobutyl-DCOPA; N-methyl-isobutyl DCOPA; 3-(3,4-bibromoanilino)-3-oxopropanoic

Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance

The role of the G-protein-coupled bile acid receptor TGR5 in various organs, tissues, and cell types, specifically in intestinal endocrine L-cells and brown adipose tissue, has made it a promising therapeutical target in several diseases, especially type-2 diabetes and metabolic syndrome. However, recent studies have shown deleterious on-target effects of systemic TGR5 agonists. To avoid these systemic effects while stimulating glucagon-like peptide-1 (GLP-1) secreting enteroendocrine L-cells, we have designed TGR5 agonists with low intestinal permeability. In this article, we describe their synthesis, characterization, and biological evaluation. Among them, compound 24 is a potent GLP-1 secretagogue, has low effect on gallbladder volume, and improves glucose homeostasis in a preclinical murine model of diet-induced obesity and insulin resistance, making the proof of concept of the potential of topical intestinal TGR5 agonists as therapeutic agents in type-2 diabetes.

IMIDAZOL- OR 1,2,4-TRIAZOL-DERIVATIVES AND THEIR USE

The present invention is directed to novel compounds of formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.