25217-40-7

Basic information

• Product Name: tert-butyl 3,4-dichlorophenylcarbamate
• Synonyms: tert-butyl 3,4-dichlorophenylcarbamate
• CAS NO: 25217-40-7
• Molecular Formula: C₁₁H₁₃Cl₂NO₂
• Molecular Weight: 262.13242
• Mol File: 25217-40-7.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 3,4-dichlorophenylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3,4-dichlorophenylcarbamate(25217-40-7)
• EPA Substance Registry System: tert-butyl 3,4-dichlorophenylcarbamate(25217-40-7)

Safety Data

• Hazardous Substances Data: 25217-40-7(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 95-76-1 m,p-dichloroaniline 
• 4248-19-5 tert-butyl carbazate 
• 95-50-1 1,2-dichloro-benzene 
• 14047-09-7 3,3',4,4'-tetrachloroazobenzene 
• 13124-18-0 3,4-dichlorophenylhydrazine 

Downstream Products

• 277301-96-9 1-(2-amino-5,6-dichlorophenyl)-2,2,2-trifluoroethanone 
• 40750-59-2 3,4-dichloro-N-methylaniline 
• 1027304-45-5 [3,4-dichloro-2-(2,2,2-trifluoroethanone)phenyl]carbamic acid tert-butyl ester 

Relevant articles and documents

Thiamine hydrochloride as a recyclable organocatalyst for the efficient and chemoselective N-tert-butyloxycarbonylation of amines

Thiamin hydrochloride promoted highly efficient and ecofriendly approach has been described for the chemoselective N-tert-butyloxycarbonylation of amines under solvent-free conditions at ambient temperature. The demonstrated approach has been applicable for the N-Boc protection of variety of aliphatic, aryl, heteroaryl amines. The chemoselective protection of amino group occurs in chiral amines and amino alcohol without racemization in high yield. Thiamin hydrochloride is stable, economical, easy to handle and environmentally friendly.

Nanoceria as an efficient and green catalyst for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions

Nanocerium oxide mediated an efficient and green protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at ambient temperature. Various aliphatic, aromatic and heteroaromatic amines were protected using developed protocol and several functional groups such as alcohol, phenol and ester were well tolerated under these conditions. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.

Teaching Old Compounds New Tricks: DDQ-Photocatalyzed C?H Amination of Arenes with Carbamates, Urea, and N-Heterocycles

The C?H amination of benzene derivatives was achieved using DDQ as photocatalyst and BocNH2 as the amine source under aerobic conditions and visible light irradiation. Electron-deficient and electron-rich benzenes react as substrates with moderate to good product yields. The amine scope of the reaction comprises Boc-amine, carbamates, pyrazoles, sulfonimides and urea. Preliminary mechanistic investigations indicate arene oxidation by the triplet of DDQ to radical cations with different electrophilicity and a charge transfer complex between the amine and DDQ as intermediate of the reaction.