4076-50-0

Usage

Organic compound

2-Amino-4'-chlorobenzophenone

Primary use

Chemical filter in sunscreens and cosmetic products

Function

UV absorber

Protection

Shields skin from UVA and UVB radiation

Photostability

High

UV protection

Broad spectrum

Safety

Approved for use in cosmetics and skincare products by FDA and European Union

Skin compatibility

Excellent

Long-lasting protection against sun's rays

Yes

Upstream product

• 31100-28-4 4-chloro-2-(toluene-4-sulfonylamino)-benzoyl chloride 
• 71-43-2 benzene 
• 34999-47-8 N-(2-benzoyl-5-chlorophenyl)acetamide 
• 108-86-1 bromobenzene 
• 38487-86-4 2-amino-4-chlorobenzonitrile 
• 92161-52-9 6-chloro-3-hydroxy-3-phenylindolin-2-one 
• 158580-85-9 4-chloro-2-(phenylsulfonamido)benzoic acid 
• 98-80-6 phenylboronic acid 
• 100-58-3 phenylmagnesium bromide 
• 708-73-6 7-chloro-2-methyl-4H-3,1-benzoxazin-4-one 
• 31100-24-0 4-chloro-2-(4-methylphenylsulfonylamino)benzoic acid 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 40928-13-0 4-chloroisatoic anhydride 
• 214971-18-3 4-chloroanthranilic acid N-methoxy-N-methylamide 

Downstream Products

• 86844-84-0 (1R,2S,6R,7S)-4-(2-Benzoyl-5-chloro-phenyl)-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]decane-3,5-dione 
• 87126-76-9 3-(2-Benzoyl-5-chloro-phenylcarbamoyl)-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid 
• 3429-07-0 1-Phenyl-1-<4-chlor-2-amino-phenyl>-aethanol 
• 3169-59-3 1-Phenyl-1-(2-amino-4-chlor-phenyl)-aethan 
• 1073843-00-1 [4-(4-benzylpiperazin-1-yl)-2-aminophenyl]phenylmethanone 
• 32011-91-9 N-(2-benzoyl-4-chlorophenyl)-2-methylprop-2-enamide 
• 195066-96-7 N-(2-benzoyl-5-chloro-phenyl)-2-chloro-acetamide 
• 120975-21-5 2-benzyl-5-chloroaniline 
• 25648-19-5 2-Amino-4-chlorobenzhydrol 

Relevant academic research and scientific papers

Asymmetric Synthesis of Hydroquinazolines Bearing C4-Tetrasubstituted Stereocenters via Kinetic Resolution of α-Tertiary Amines

A novel protocol for asymmetric synthesis of hydroquinazolines bearing C4-tetrasubstituted stereocenters has been achieved through kinetic resolution of 2-amido α-tertiary benzylamines via chiral phosphoric acid catalyzed intramolecular dehydrative cyclizations. This method gave access to both α-tertiary benzylamines and hydroquinazolines with broad scope and high enantioselectivities. An intriguing restricted rotation of the C-N bond was observed for hydroquinazoline products bearing C4-tetrasubstituted stereocenters.

One-Pot Synthesis of 2-Aminobenzophenones from 2-Alkynyl Arylazides Catalyzed by Pd and Cu Precursors

We describe a novel one-pot three-step reaction of 2-alkynyl arylazides through palladium-catalyzed formation of 3-hydroxy-3-phenylindolin-2-ones followed by hydrolysis of amide bonds and copper-catalyzed decarboxylation to give 2-aminobenzophenones. This synthetic method works well with various 2-alkynyl arylazides and affords the products in moderate to good yields under mild reaction conditions.

Palladium(II)-Catalyzed Three-Component Tandem Cyclization Reaction for the One-Pot Assembly of 4-Arylquinazolines

A one-pot method for joining three separate components leading to an assortment of 4-arylquinazolines (27 examples) in good to excellent yields is described. The method consists of a palladium(II)-catalyzed?-cascade reaction involving C(sp)-C(sp 2/s

Synthesis of 1-Amino-2,2,2-trifluoroalkylphosphonates from Alkene-Tethered Trifluoroacetimidoyl Chlorides

The reaction of alkene-tethered trifluoroacetimidoyl chlorides with trialkyl phosphites furnishes 1-amino-2,2,2-trifluoroalkylphosphonates. The products were generated in moderate to good yields, and the scalability of this process was showcased. Partial hydrolysis of the phosphonate moiety was achieved. The cyclization is proposed to occur via formation of an imidoyl phosphonate intermediate that becomes susceptible to nucleophilic attack at nitrogen through the strong electron-withdrawing groups at the imidoyl carbon.

One-Pot Synthesis of Spirocyclopenta[ a]indene Derivatives via a Cascade Ring Expansion and Intramolecular Friedel-Crafts-Type Cyclization

A one-pot efficient synthetic approach for the rapid construction of spirocyclopenta[a]indene derivatives has been developed via an iodine-initiated cascade ring expansion and intramolecular Friedel-Crafts-type cyclization from propargyl alcohol-tethered alkylidenecyclobutanes under mild conditions with broad substrate scope. This cascade process can be elegantly conducted on a gram scale. A plausible reaction mechanism has been proposed on the basis of a series of deuterium labeling and control experiments.

Visible Light Induced Cyclization to Spirobi[indene] Skeletons from Functionalized Alkylidienecyclopropanes

In this paper, we revealed a metal-free and visible light photoinduced method for the rapid construction of spirobi[indene] skeletons, providing a simple and efficient way for easy access to spirobi[indene] scaffolds under mild conditions along with a broad substrate scope and good functional group tolerance.

Palladium-Catalyzed Cascade Reductive and Carbonylative Cyclization of Ortho-Iodo-Tethered Methylenecyclopropanes (MCPs) Using N-Formylsaccharin as CO Source

A palladium-catalyzed reductive and carbonylative cyclization of ortho-iodo-tethered methylenecyclopropanes (MCPs) using N-formylsaccharin as CO source has been developed, affording the desired indanone derivatives in moderate to good yields with high regio- and stereoselectivity and good functional group compatibility.

Synthesis of Diiodinated All-Carbon 3,3′-Diphenyl-1,1′-spirobiindene Derivatives via Cascade Enyne Cyclization and Electrophilic Aromatic Substitution

A synthetic method for the construction of diiodinated all-carbon spirobiindene derivatives has been developed from the reaction of propargyl alcohol-tethered alkylidenecyclopropanes with iodine. The reaction proceeded through an iodination-initiated cascade intramolecular enyne cyclization and electrophilic aromatic substitution reaction process in 1,2-dichloroethane upon heating, giving desired spirocyclic products in moderate to excellent yields. Further transformation of the obtained products has also been presented.

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration

An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction of an enhanced library of unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage of a stronger C?O bond and formation of a weaker C?C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.

Cascade Amination/Cyclization/Aromatization Process for the Rapid Construction of [2,3-c]Dihydrocarbazoles and [2,3-c]Carbazoles

An intramolecular cascade amination/cyclization/aromatization reaction of functionalized alkylidenecyclopropanes has been developed in the presence of silver acetate, affording a variety of [2,3-c]dihydrocarbazoles and [2,3-c]carbazoles in moderate to excellent yields. The mechanistic investigations revealed that this cascade reaction proceeds through a radical initiated process. Moreover, further transformations for the synthesis of eustifoline-D and an OLED exhibit a potential synthetic utility of this method.