407629-40-7Relevant academic research and scientific papers
SCMTR: A chloride-selective, membrane-anchored peptide channel that exhibits voltage gating
Schlesinger, Paul H.,Ferdani, Riccardo,Liu, Jun,Pajewska, Jolanta,Pajewski, Robert,Saito, Mitsuyoshi,Shabany, Hossein,Gokel, George W.
, p. 1848 - 1849 (2002)
The design, synthesis, and characterization of a synthetic chloride membrane transporter, SCMTR (synthetic chloride membrane transporter, "scimitar"), are presented. The compound [CH3(CH2)17]2NCOCH2OC
A hydrocarbon anchored peptide that forms a chloride-selective channel in liposomes.
Schlesinger, Paul H,Ferdani, Riccardo,Pajewski, Robert,Pajewska, Jolanta,Gokel, George W
, p. 840 - 841 (2002)
The heptapeptide sequence Gly-Gly-Gly-Pro-Gly-Gly-Gly, when anchored to diglycolic acid derived (C18H37)2NCOCH2OCH2COOH, forms chloride-selective ion channels in phospholipid liposomes but the related heptapeptide Gly-Gly-Gly-Leu-Gly-Gly-Gly, and tripepti
COMPOSITIONS AND METHODS FOR SYNTHETIC AMPHIPHILE-INDUCED CHANGES IN PLANT ROOT MORPHOLOGY
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Paragraph 0125, (2016/04/04)
The disclosure provides a method for increasing the lateral root development of a plant by exposing said plant to a composition containing a synthetic amphiphile. By increasing the number of lateral roots, the surface area of the root structure is increased, making the plants better able to survive such stresses as drought or low nutrients
Aggregation and supramolecular membrane interactions that influence anion transport in tryptophan-containing synthetic peptides
Daschbach, Megan M.,Negin, Saeedeh,You, Lei,Walsh, Matthew,Gokel, George W.
, p. 7608 - 7623 (2012/07/28)
Self-assembly is a desired property in supramolecular chemistry, but extensive aggregation may be counterproductive. Rigid systems typically have better organization, but are inherently less dynamic. This work shows that ion transport by amphiphilic hepta
Fluorescent, synthetic amphiphilic heptapeptide anion transporters: Evidence for self-assembly and membrane localization in liposomes
You, Lei,Gokel, George W.
body text, p. 5861 - 5870 (2009/05/31)
Synthetic anion transporters (SATs) of the general type (n-C 18H37)2N-COCH2OCH 2CO-(Gly)3-Pro-(Gly)3-O-n-C7H 15, 1, are amphiphilic peptides that form anion
Cation dependence of chloride ion complexation by open-chained receptor molecules in chloroform solution
Pajewski, Robert,Ferdani, Riccardo,Pajewska, Jolanta,Li, Ruiqiong,Gokel, George W.
, p. 18281 - 18295 (2007/10/03)
Seventeen peptides, most having the sequence GGGPGGG, but differing in the C- and N-terminal ends, have been studied as anion-complexing agents. These relatively simple, open-chained peptide systems interact with both chloride and the associated cation. Changes in the N- and C-terminal side chains appear to make little difference in the efficacy of binding. NMR studies suggest that the primary interactions involve amide NH contacts with the chloride anion, and CD spectral analyses suggest a concomitant conformational change upon binding. Changes in binding constants, which are expected in different solvents, also suggest selective solvent interactions with the unbound host that helps to preorganize the open-chained peptide system. Significant differences are apparent in complexation strengths when the heptapeptide chain is shortened or lengthened or when the relative position of proline within the heptapeptide is varied.
Replacing proline at the apex of heptapeptide-based chloride ion transporters alters their properties and their ionophoretic efficacy
Schlesinger, Paul H.,Ferdani, Riccardo,Pajewska, Jolanta,Pajewski, Robert,Gokel, George W.
, p. 60 - 67 (2007/10/03)
A membrane anchored heptapeptide, (C18H37)2NHCOCH2OCH 2CO-NH-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OCH2Ph, has proved to be a selective chloride anion transporter that functions in phospholipid bilay
