4078-59-5

Upstream product

• 56-40-6 glycine 
• 13248-54-9 cyclohexyl chloroformate 
• 91333-92-5 N-Cyclohexyloxycarbonyl-glycin-ethylester 
• 108-93-0 cyclohexanol 
• 2949-22-6 Glycine ethyl ester isocyanate 

Downstream Products

• 3886-35-9 CCO-Gly-Gly 
• 4474-73-1 CCO-Gly-Gly-OCH₃ 
• 500895-09-0 cyclohexyl 2-[4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-piperidinyl]-2-oxoethylcarbamate 
• 3998-48-9 Cyclohexyloxycarbonyl-glycin-anilid 
• 3998-49-0 CCO-Gly-butylamid 
• 3886-36-0 CCO-Gly-amid 
• 4009-61-4 (2-Cyclohexyloxycarbonylamino-acetylamino)-acetic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

NOVEL DIARYLALKENE DERIVATIVES AND NOVEL DIARYLALKANE DERIVATIVES

The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH=CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V--W represents C=C, etc., n represents 0 to 3, Y1 represents O etc., B represents--(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents--CO--, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group,--COR18a,--COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.

MEDICINAL COMPOSITIONS CONTAINING GABAPENTIN OR PREGABALIN AND N-TYPE CALCIUM CHANNEL ANTAGONIST

The present invention relates to a pharmaceutical composition useful for preventing/treating pain, which comprises combination of gabapentin or pregabalin, or pharmaceutically acceptable salts thereof and N-type calcium channel antagonists or pharmaceutically acceptable salts thereof such as a compound having the following structure.

Cyclohexyloxycarbonyl based orthogonal solid phase peptide synthesis in Boc chemistry

Application of N-cyclohexyloxocarbonyl (Choc) protection in Boc chemistry on solid phase provides a new possibility for the preparation of protected peptide fragments. A Choc/OcHex protection scheme allows also the assembly of cyclic lactam peptides linked to the resin through the C- terminus. Choc protection is stable under the 1M TMSOTf-thioanisole/TFA cleavage condition at 0°C, but it is removable by anhydrous HF. We have utilized cyclohexyloxycarbonyl as an orthogonal protecting group for the synthesis of a i) bicyclic epitope peptide of glycoprotein D of HSV 1 on BHA resin and ii) fully protected hexapeptide involved in protein transport on Merrifield resin.