40784-88-1

Basic information

• Product Name: ETHYL 4-ETHOXYPHENYLACETATE
• Synonyms: ETHYL 4-ETHOXYPHENYLACETATE;4-Ethoxyphenylacetic acid ethyl ester;Ethyl 4-ethoxyphenylacetate, 95+%;Ethyl 4-ethoxyphenylacetate, 97+%
• CAS NO: 40784-88-1
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.25
• Product Categories: Aromatic Esters
• Mol File: 40784-88-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 112-113°C 0,5mm
• Flash Point: 112-113°C/0.5mm
• Appearance: /
• Density: 1.045 g/cm³
• Vapor Pressure: 0.00224mmHg at 25°C
• Refractive Index: 1.5020
• BRN: 2969074
• CAS DataBase Reference: ETHYL 4-ETHOXYPHENYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-ETHOXYPHENYLACETATE(40784-88-1)
• EPA Substance Registry System: ETHYL 4-ETHOXYPHENYLACETATE(40784-88-1)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 40784-88-1(Hazardous Substances Data)

Usage

General Description

Ethyl 4-ethoxyphenylacetate is a chemical compound with the molecular formula C12H16O3. It is an ester, which means it is formed from the reaction between an acid and an alcohol. ETHYL 4-ETHOXYPHENYLACETATE is commonly used as a flavoring agent in the food and beverage industry due to its pleasant, fruity aroma. It is also used in the production of fragrances, perfumes, and cosmetics. Additionally, ethyl 4-ethoxyphenylacetate is used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is important to handle this chemical with care, as it can be harmful if ingested or inhaled and may cause skin and eye irritation.

InChI:InChI=1/C12H16O3/c1-3-14-11-7-5-10(6-8-11)9-12(13)15-4-2/h5-8H,3-4,9H2,1-2H3

Upstream product

• 4919-33-9 4-ethoxyphenylacetic acid 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 622-60-6 1-ethoxy-4-methylbenzene 
• 106-41-2 4-bromo-phenol 
• 105-53-3 diethyl malonate 
• 156-38-7 4-hydroxyphenylacetate 
• 74-96-4 ethyl bromide 

Downstream Products

• 872300-04-4 1,1,2-tris-(4-ethoxy-phenyl)-ethanol 
• 80768-40-7 ethyl 2-(4-ethoxyphenyl)pent-4-enoate 
• 1297493-00-5 ethyl 2,4-bis(4-ethoxyphenyl)-5-oxo-2,5-dihydro-1H-imidazole-2-carboxylate 
• 107714-92-1 ethyl 2-(4-ethoxyphenyl)-3,3,3-trifluoropropanoate 
• 107713-58-6 3-(4-chlorophenoxy)benzyl (RS)-2-(4-ethoxyphenyl)-3,3,3-trifluoropropyl ether 
• 4919-33-9 4-ethoxyphenylacetic acid 
• 63935-52-4 2-(4-ethoxyphenyl)propenoic acid ethyl ester 
• 72370-82-2 1-(4-ethoxyphenyl)cyclobutane carboxylic acid 
• 373361-59-2 ethyl 2-[3-(chlorosulfonyl)-4-ethoxyphenyl]acetate 
• 181701-45-1 ethyl bromo(4-ethoxyphenyl)acetate 
• 124131-83-5 tris-(4-ethoxy-phenyl)-bromo-ethene 
• 135043-37-7 1-bromo-1-(p-ethoxyphenyl)-2,2-bis(p-methoxyphenyl)ethene 
• 344345-19-3 3-phenoxybenzyl 2-(4-ethoxyphenyl)-3-(2,2,3,3-tetrafluorocyclobutyl)propanoate 
• 345300-47-2 ethyl 2-(4-ethoxyphenyl)-3-(2,2,3,3-tetrafluorocyclobutyl)propanoate 

Relevant articles and documents

PROCESS FOR SYNTHESIZING PHENYLACETIC ACID BY CARBONYLATION OF TOLUENE

A production process for substituted phenylacetic acids or ester analogues thereof is disclosed. In this process toluene or toluene substituted with various substituents, an alcohol, an oxidant and carbon monoxide are used as raw materials to obtain compounds comprising structure of phenylacetic acid ester or analogues thereof by catalysis of the complex catalyst formed from transition metal and ligand, and such compounds are hydrolyzed to obtain various substituted phenylacetic acid based compounds. This type of compounds and their derivatives serve as important fine chemicals used widely in the industries of pharmaceuticals, pesticides, perfume and the like.

Practical synthesis of 2-arylacetic acid esters via palladium-catalyzed dealkoxycarbonylative coupling of malonates with aryl halides

A new palladium-based system was developed that catalyzes the coupling of aryl halides with diethyl malonates in the presence of mild bases. In the course of the reaction, the intermediately formed diethyl arylmalonate is directly converted into the arylacetic acid ester via liberation of carbon dioxide and an alkanol. This cross-coupling/dealkoxycarbonylation process provides an efficient and high-yielding synthetic entry to diversely functionalized arylacetic acid esters. Two complementary protocols were developed, one of which is optimal for electron-rich, the other for electron-poor aryl halides. Both make use of low loadings of palladium(0) bis(dibenzylideneacetone) (0.5 mol%)/tri-tert-butylphosphonium tetrafluoroborate (1.1 mol%) as the catalyst and diethyl malonate as the reaction solvent. The new procedures are particularly effective for sterically hindered substrates. Copyright

Growth hormone secretagogues

What is disclosed are growth hormone secretagogues, and their uses, of the formula wherein R1 is C6H5CH2OCH2—, C6H5(CH2)3— or indol-3-ylmethyl; Y is pyrrolidin-1-yl, 4-C1-C6alkylpiperidin-1-yl or NR2R2; R2 are each independently a C1to C6alkyl; R3 is 2-napthyl or phenyl para-substituted by W; W is H, F, CF3, C1-C6alkoxy or phenyl; and R4 is H or CH3, or a pharmaceutically acceptable salt or solvate thereof.