ETHYL 4-ETHOXYPHENYLACETATE

Base Information

• Chemical Name: ETHYL 4-ETHOXYPHENYLACETATE
• CAS No.: 40784-88-1
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Hs Code.: 2918990090
• Mol file: 40784-88-1.mol

Synonyms:Ethyl(4-ethoxyphenyl)acetate;Ethyl (p-ethoxyphenyl)acetate;Ethyl2-(4-ethoxyphenyl)acetate;

Chemical Property of ETHYL 4-ETHOXYPHENYLACETATE

Chemical Property:

• Vapor Pressure: 0.00224mmHg at 25°C
• Refractive Index: 1.5020
• Boiling Point: 289.2 °C at 760 mmHg
• Flash Point: 116.8 °C
• PSA: 35.53000
• Density: 1.045 g/cm³
• LogP: 2.19090

Purity/Quality:

99% ^*data from raw suppliers

Ethyl4-ethoxyphenylacetate ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 4-ETHOXYPHENYLACETATE

There total 6 articles about ETHYL 4-ETHOXYPHENYLACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-bromo-phenol (106-41-2) + diethyl malonate (105-53-3) → ethyl 4-ethoxyphenylacetate (40784-88-1)

Guidance literature:

With potassium phosphate; 18-crown-6 ether; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; at 160 ℃; for 8h; Inert atmosphere;

DOI:10.1002/adsc.201100102

Reference yield: 86.0%

ethanol (64-17-5) + carbon monoxide (201230-82-2) + 1-ethoxy-4-methylbenzene (622-60-6) → ethyl 4-ethoxyphenylacetate (40784-88-1)

Guidance literature:

With di-tert-butyl peroxide; dichloro[4,5-bis(diphenylphosphino)-9,9’-dimethylxanthene]palladium(II); at 120 ℃; for 16h; under 7600.51 Torr;

Reference yield: 86.0%

→ ethyl 4-ethoxyphenylacetate (40784-88-1)

Guidance literature:

upstream raw materials:

4-ethoxyphenylacetic acid

ethanol

ethyl bromide

4-hydroxyphenylacetate

Downstream raw materials:

1,1,2-tris-(4-ethoxy-phenyl)-ethanol

2-(4-ethoxy-phenyl)-1,1-bis-(4-propoxy-phenyl)-ethanol

1-(4-ethoxyphenyl)cyclobutane carboxylic acid

4-ethoxyphenylacetic acid

Refernces

• 1、 Xie, Pan,Xie, Yinjun,Qian, Bo,Zhou, Han,Xia, Chungu,Huang, Hanmin. "Palladium-catalyzed oxidative carbonylation of benzylic C-H bonds via nondirected C(sp3)-H activation". supporting information; experimental part. p. 9902 - 9905. Retrieved 2012/08/08.
• 2、 Gao,Zhao,Liu,Shao,Wang,Tang,Wang. "Design, synthesis and in vivo hypoglycemic activity of tetrazole-bearing N-glycosides as SGLT2 inhibitors". experimental part. p. 1499 - 1508. Retrieved 2011/02/22.