408321-74-4

Upstream product

• 1670-14-0 benzamidine monohydrochloride 
• 82979-45-1 methyl 2-chloro-2-cyclopropylideneacetate 

Downstream Products

• 34127-13-4 2-phenyl-5,6,7,8-tetrahydronquinazolin-4(3H)-one 
• 908010-00-4 tert-butyl 4-oxo-2-phenyl-6-(phenylsulfonyl)-5,6,7,8-tetrahydro-3H-quinazoline-3-carboxylate 
• 908009-91-6 2-phenyl-6-(phenylsulfonyl)-4-trimethylsilyloxy-5,6,7,8-tetrahydro-3H-quinazoline 
• 908009-93-8 6-ethyl-2-phenyl-6-(phenylsulfonyl)-5,6,7,8-tetrahydro-3H-quinazolin-4-one 
• 908009-92-7 6-methyl-2-phenyl-6-(phenylsulfonyl)-5,6,7,8-tetrahydro-3H-quinazolin-4-one 
• 909299-07-6 6-ethyl-2-phenyl-7,8-dihydro-3H-quinazolin-4-one 
• 909299-06-5 6-methyl-2-phenyl-7,8-dihydro-3H-quinazolin-4-one 
• 908009-84-7 2-phenyl-7,8-dihydro-3H-quinazolin-4-one 
• 908009-77-8 2-phenyl-6-(phenylsulfonyl)-5,6,7,8-tetrahydro-3H-quinazolin-4-one 

Relevant academic research and scientific papers

Access to variously substituted 5,6,7,8-tetrahydro-3H-quinazolin-4-ones via Diels-Alder adducts of phenyl vinyl sulfone to cyclobutene-annelated pyrimidinones

Under basic conditions (Et3N, dioxane), the aromatic amidines 4 and also S-methylisothiourea 4g cleanly undergo Michael addition to methyl 2-chloro-2-cyclopropylideneacetate (5), followed by intramolecular nucleophilic substitution, cyclopropyl

TETRAHYDRO- AND DIHYDROQUINAZOLINONES

The present invention relates to the use of tetrahydro- and dihydroquinazolinones of formula (I) as protein kinase activators or inhibitors, a method for their manufacture, their use for the preparation of a medicament for the treatment of diseases, their

Domino reactions of amidines with methyl 2-chloro-2-cyclopropylideneacetate as an efficient access to cyclobutene-annelated pyrimidinones

(equation presented) An efficient one-step synthesis of 2,4-diazabicyclo[4.2.0]octa-1(6),2-dien-5-ones 3 from methyl 2-chloro-2-cyclopropylideneacetate (1) and amidines 2a-c as well as N,N-dimethylguanidine (2d) is described. Similar to the benzocyclobute