34127-13-4

Upstream product

• 618-39-3 benzamidin 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 2981-10-4 1-(cyclohex-1-en-1-yl)piperidine 
• 4461-33-0 benzoyl isocyanate 
• 936-52-7 1-(N-morpholino)cyclopent-1-ene 
• 670-80-4 4-cyclohexen-1-ylmorpholine 
• 1670-14-0 benzamidine monohydrochloride 
• 105687-40-9 2-(3'-cyclohexenyl)-1,2,5,6,7,8-hexahydroquinazolin-4(3H)-one 
• 62582-90-5 2-Phenyl-5,6-tetramethylen-1,2-dihydropyrimidin-4(3H)-on 
• 22945-27-3 cyclohexanone-2-carboxamide 
• 100-50-5 3-Cyclohexene-1-carboxaldehyde 
• 68965-62-8 2-bromocyclohex-1-enecarboxylic acid 
• 552857-10-0 2-bromo-N-phenyl-1-cyclohexene-1-carboxamide 
• 100-52-7 benzaldehyde 

Downstream Products

• 1436866-28-2 ethyl 2-[4-[(2-phenyl-5,6,7,8-tetrahydroquinazolin-4-yl)amino]phenyl]acetate 
• 1436866-29-3 2-[4-[(2-phenyl-5,6,7,8-tetrahydroquinazolin-4-yl)amino]phenyl]acetic acid 
• 1436866-27-1 (2-phenyl-5,6,7,8-tetrahydroquinazolin-4-yl) trifluoromethanesulfonate 

Relevant academic research and scientific papers

Microwave-assisted copper powder-catalyzed coupling and cyclization of β-bromo-α,β-unsaturated amides with amidine hydrochlorides leading to pyrimidinones

β-Bromo-α,β-unsaturated amides are coupled and cyclized with amidine hydrochlorides using microwave irradiation in the presence of a catalytic amount of copper powder and a base to give the corresponding pyrimidinones in good yields.

Microwave-assisted copper-powder-catalyzed synthesis of pyrimidinones from β-bromo α,β-unsaturated carboxylic acids and amidines

β-Bromo α,β-unsaturated carboxylic acids were coupled and cyclized with amidine hydrochlorides by microwave irradiation in the presence of catalytic amounts of copper powder and a base to give the corresponding pyrimidinones in high yields. Georg Thieme Verlag Stuttgart New York.

Fe3O4 nanoparticle-supported copper(I): Magnetically recoverable and reusable catalyst for the synthesis of quinazolinones and bicyclic pyrimidinones

A highly efficient, easily recoverable and reusable Fe3O 4 magnetic nanoparticle-supported Cu(I) catalyst has been developed for the synthesis of quinazolinones and bicyclic pyrimidinones. In the presence of supported Cu(I) catalyst (10 mol%), amidines reacted with substituted 2-halobenzoic acids and 2-bromocycloalk-1-enecarboxylic acids to generate the corresponding N-heterocycle products in good to excellent yields at room temperature in DMF. In addition, the supported Cu(I) catalyst could be recovered at least 10 times without significant loss of its catalytic activity. Copyright

Easy and efficient copper-catalyzed synthesis of bicyclic pyrimidinones under mild conditions

A simple and efficient copper-catalyzed method has been developed for synthesis of bicyclic pyrimidinones containing six-, seven-, eight-membered rings under mild conditions. The protocol uses readily available 2-bromocycloalk-1-enecarboxylic acids, amidines, and guanidines as the starting materials, copper-catalyzed cascade couplings provide the corresponding bicyclic pyrimidinones without addition of any ligand or additive, and the method is of economical and practical advantages. Georg Thieme Verlag Stuttgart New York.

Access to variously substituted 5,6,7,8-tetrahydro-3H-quinazolin-4-ones via Diels-Alder adducts of phenyl vinyl sulfone to cyclobutene-annelated pyrimidinones

Under basic conditions (Et3N, dioxane), the aromatic amidines 4 and also S-methylisothiourea 4g cleanly undergo Michael addition to methyl 2-chloro-2-cyclopropylideneacetate (5), followed by intramolecular nucleophilic substitution, cyclopropyl

TETRAHYDRO- AND DIHYDROQUINAZOLINONES

The present invention relates to the use of tetrahydro- and dihydroquinazolinones of formula (I) as protein kinase activators or inhibitors, a method for their manufacture, their use for the preparation of a medicament for the treatment of diseases, their

POLY(ADP-RIBOSE) POLYMERASE INHIBITORS CONSISTING OF PYRIMIDINE DERIVATIVES

A medicament for therapeutic and/or preventive treatment of a brain disease, which comprises a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient: wherein R represents hydrogen atom, a C1-C8 alkyl group, a substituted C1-C8 alkyl group, an aryl group, a substituted aryl group, an aryl(C1-C8)alkyl group and the like; Y represents hydrogen atom or -C(R2)R3 (R2 and R3 represent hydrogen atom, a C1-C8 alkyl group, a C1-C8 alkoxy(C1-C8)alkyl group, a hydroxy(C1-C8)alkyl group and the like); symbol "a" represents single bond when Y represents hydrogen atom, or "a" represents double bound when Y represents -C(R2)R3; -A-B- represents -CH2-CH2-, -S-CH2-, -O-CH2-, -CH2-S-, -CH2-O-, -SO-CH2-, -CH2-SO-, -SO2-CH2-, or -CH2-SO2-; and Z represents -CH2- or single bond.

A Novel Ring Transformation of Oxazinones and Azetidinones into Pyrimidinones

Azetidinones or oxazinones, being easily prepared from enamines and acyl isocyanates, were transformed into highly substituted 4(3H)-pyrimidinones upon treatment with ammonium acetate.This novel ring transformation was also accomplished through a one-pot

A Novel Preparation of 5,6,7,8-Tetrahydroquinazolin-4(3H)-ones

Cyclocondensation of 2-oxocyclohexanecarboxamide with aldehydes and ammonia affords 4-oxo-1,2,5,6,7,8-hexahydroquinazolines which are conveniently dehydrogenated to the title compounds by treatment with palladium-on-carbon catalyst in boiling toluene.