408336-54-9

Basic information

• Product Name: N-(4-methoxybenzyl)-2-(4-methoxyphenyl)ethanamine
• CAS NO: 408336-54-9
• Molecular Formula: C₁₇H₂₁NO₂
• Molecular Weight: 271.3541
• Mol File: 408336-54-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 406.4°C at 760 mmHg
• Flash Point: 171.2°C
• Density: 1.058g/cm³
• Vapor Pressure: 8.17E-07mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: N-(4-methoxybenzyl)-2-(4-methoxyphenyl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxybenzyl)-2-(4-methoxyphenyl)ethanamine(408336-54-9)
• EPA Substance Registry System: N-(4-methoxybenzyl)-2-(4-methoxyphenyl)ethanamine(408336-54-9)

Safety Data

• Hazardous Substances Data: 408336-54-9(Hazardous Substances Data)

Upstream product

• 55-81-2 4-Methoxyphenethylamine 
• 25413-27-8 3-(4-methoxy-phenyl)propionamide 
• 637-69-4 4-Methoxystyrene 
• 2393-23-9 4-methoxy-benzylamine 

Relevant articles and documents

Base-catalyzed anti-Markovnikov hydroamination of vinylarenes - Scope, limitations and computational studies

The hydroamination of vinylarenes with primary and secondary amines was studied with catalytic amounts as low as 2 mol-% of LiN(SiMe3) 2/TMEDA. Reactions proceeded readily at 120°C in the absence of solvent to give selective anti-Markovnikov addition. Slow addition was observed at 25°C with either electron-deficient p-chlorostyrene or secondary cyclic amines such as pyrrolidine, piperidine, or morpholine. Primary amines were prone to a second hydroamination reaction to form tertiary amine byproducts. The selectivity for the mono(hydroamination) products could be improved with a two-fold excess of the amine. KN(SiMe3)2 showed higher catalytic activity but lower selectivity in comparison to that of LiN(SiMe 3)2, resulting in undesired C-H-activation by-products. The mechanism of the lithium-catalyzed hydroamination and the influence of TMEDA was studied with density functional theory. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.