25413-27-8

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-Methoxyphenyl)propionamide is used as a pharmaceutical intermediate for the synthesis of various pharmaceutical drugs. Its unique chemical structure allows it to be a key component in the development of new medications, contributing to the advancement of healthcare and treatment options.
Used in Drug Synthesis:
3-(4-Methoxyphenyl)propionamide is used as a building block in the synthesis of pharmaceutical compounds. Its versatile chemical properties enable it to be incorporated into a wide range of drug molecules, enhancing their therapeutic effects and improving patient outcomes.
It is important to handle 3-(4-Methoxyphenyl)propionamide with care, as it may be harmful if ingested, inhaled, or comes into contact with the skin. Additionally, it may cause irritation to the eyes, skin, and respiratory system. Proper safety measures should be taken during its use to ensure the well-being of individuals involved in its production and application.

Upstream product

• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 
• 15823-04-8 methyl 3-(4-methoxyphenyl)propionate 
• 15893-42-2 3-(4-methoxyphenyl)propionyl chloride 
• 36650-51-8 (2E)-3-(4-methoxyphenyl)acrylamide 
• 36650-51-8 4-methoxycinnamic acid amide 
• 637-69-4 4-Methoxystyrene 
• 201230-82-2 carbon monoxide 
• 77287-34-4 formamide 
• 60-35-5 acetamide 
• 105-13-5 4-Methoxybenzyl alcohol 
• 121-97-1 4-Methoxypropiophenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 3901-07-3 3-(4-methoxy-phenyl)acrylic acid methyl ester 
• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 

Downstream Products

• 5406-18-8 3-(p-methoxyphenyl)-1-propanol 
• 22442-48-4 3-(4-methoxyphenyl)propionitrile 
• 55-81-2 4-Methoxyphenethylamine 
• 51-67-2 tyrosamine 
• 20401-88-1 3-(4-methoxyphenyl)propional 
• 91337-83-6 3-(4-methoxy-phenyl)-propionaldehyde-semicarbazone 
• 82267-46-7 DL-2-amino-4-(p-methoxyphenyl)butanoic acid 
• 41350-95-2 1-(4-hydroxy-2,6-dimethoxy-phenyl)-3-(4-methoxy-phenyl)-propan-1-one 
• 3791-75-1 2'-hydroxy-4,4',6'-trimethoxydihydrochalcone 
• 91247-71-1 2-4-methoxyphenylethylcarbamic acid methyl ester 
• 1158074-50-0 N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dimethylpropyl]-3-(4-methoxyphenyl)propanamide 
• 1976-98-3 (4-hydroxyphenethyl)trimethylammonium iodide 
• 175287-92-0 N-(4-methoxy-phenethyl)-benzenesulfonamide 
• 119045-87-3 N-ethyl-p-tyramine 

Relevant academic research and scientific papers

Photoinduced Aerobic Iodoarene-Catalyzed Spirocyclization of N-Oxy-amides to N-Fused Spirolactams**

Iodoarene catalysis is a powerful methodology that usually requires an excess of oxidant, or of redox mediator if the terminal oxidant is dioxygen, to generate the key hypervalent iodine intermediate to proceed efficiently. We report that, using the spiro-cyclization of amides as a benchmark reaction, aerobic iodoarene catalysis can be enabled by relying on a pyrylium photocatalyst under blue light irradiation. This unprecedented dual organocatalytic system allows the use of low catalytic loading of both catalysts under very mild operating conditions.

Visible light-mediated synthesis of amides from carboxylic acids and amine-boranes

Here, a photocatalytic deoxygenative amidation protocol using readily available amine-boranes and carboxylic acids is described. This approach features mild conditions, moderate-to-good yields, easy scale-up, and up to 62 examples of functionalized amides with diverse substituents. The synthetic robustness of this method was also demonstrated by its application in the late-stage functionalization of several pharmaceutical molecules.

Visible-Light Decatungstate/Disulfide Dual Catalysis for the Hydro-Functionalization of Styrenes

We describe an efficient photoredox system, relying on decatungstate/disulfide catalysts, for the hydrofunctionalization of styrenes. In this methodology the use of disulfide as a cocatalyst was shown to be crucial for the reaction efficiency. This photoredox system was employed for the hydro-carbamoylation, -acylation, -alkylation, and -silylation of styrenes, giving access to a large variety of useful building blocks and high-value molecules such as amides and unsymmetrical ketones from simple starting materials.

Direct synthesis of amides from nonactivated carboxylic acids using urea as nitrogen source and Mg(NO3)2or imidazole as catalysts

A new method for the direct synthesis of primary and secondary amides from carboxylic acids is described using Mg(NO3)2·6H2O or imidazole as a low-cost and readily available catalyst, and urea as a stable, and easy to manipulate nitrogen source. This methodology is particularly useful for the direct synthesis of primary and methyl amides avoiding the use of ammonia and methylamine gas which can be tedious to manipulate. Furthermore, the transformation does not require the employment of coupling or activating agents which are commonly required.

Nickel-catalyzed: C-alkylation of thioamide, amides and esters by primary alcohols through a hydrogen autotransfer strategy

A simple catalyst of Ni(OAc)2 and P(t-Bu)3 enables selective C-alkylation of thioacetamides and primary acetamides with alcohols for the first time. Monoalkylation of thioamides, amides and t-butyl esters occurs in excellent yields (>95%). Mechanistic studies reveal that the reaction proceeds via a hydrogen autotransfer pathway. This journal is

Primary fatty acid amide preparation method

The present invention provides a primary fatty acid amide preparation method. According to the present invention, under the action of a single auxiliary agent phosphine-containing transition metal catalyst or a combined auxiliary agent comprising a phosphine-free transition metal catalyst and a phosphine-containing ligand, terminally substituted olefin or cyclo-olefin, carbon monoxide and an ammonium salt are subjected to a hydrogen carboamidation reaction so as to prepare the primary fatty acid amide compound in one step; the raw material and the catalyst of the reaction are inexpensive and easy to obtain, and the synthesis process is simple, such that the synthesis cost is substantially reduced; the preparation method has characteristics of mild reaction condition and high yield, and issuitable for industrial production; and the raw material and the catalyst of the reaction are clean, non-toxic and low environment pollution.

Palladium-catalyzed regiodivergent hydroaminocarbonylation of alkenes to primary amides with ammonium chloride

Palladium-catalyzed hydroaminocarbonylation of alkenes for the synthesis of primary amides has long been an elusive aim. Here, we report an efficient catalytic system which enables inexpensive NH4Cl to be utilized as a practical alternative to gaseous ammonia for the palladium-catalyzed alkene-hydroaminocarbonylation reaction. Through appropriate choice of the palladium precursors and ligands, either branched or linear primary amides can be obtained in good yields with good to excellent regioselectivities. Primary mechanistic studies were conducted and disclosed that electrophilic acylpalladium species were capable of capturing the NH2-moiety from ammonium salts to form amides in the presence of CO with NMP as a base.

METHODS AND COMPOSITIONS FOR SELECTIVE AND TARGETED CANCER THERAPY

Provided herein are methods and compositions for selective and targeted cancer therapy, in particular certain benzothiophenes, benzothiazoles, oxalamides, N-acyl ureas and chromones, and their use in selectively treating certain adenocarcinomas. In some embodiments, the selective toxicity of the compounds may be mediated through SCD1 and/or CYP450 such as CYP4F11.

Chemoselective hydrogenation of the olefinic bonds using a palladium/magnesium-lanthanum mixed oxide catalyst

A palladium/magnesium-lanthanum mixed oxide catalyst is found to be an efficient heterogeneous catalyst for the chemoselective hydrogenation of olefinic double bonds in the presence of various functional groups. The catalyst was recovered by centrifugation and reused for several cycles with consistent activity and selectivity. Copyright

Discovery and biological evaluation of novel cyanoguanidine P2X7 antagonists with analgesic activity in a rat model of neuropathic pain

We disclose the design of a novel series of cyanoguanidines that are potent (IC50 ? 10-100 nM) and selective (≥100-fold) P2X7 receptor antagonists against the other P2 receptor subtypes such as the P2Y2, P2X4, and P2X3. We also found that these P2X7 antagonists effectively reduced nociception in a rat model of neuropathic pain (Chung model). Particularly, analogue 53 proved to be effective in the Chung model, with an ED50 of 38 μmol/kg after intraperitoneal administration. In addition compound 53 exhibited antiallodynic effects following oral administration and maintained its efficacy following repeated administration in the Chung model. These results suggest an important role of P2X7 receptors in neuropathic pain and therefore a potential use of P2X7 antagonists as novel therapeutic tools for the treatment of this type of pain.