408354-40-5Relevant articles and documents
Design and synthesis of (aza)indolyl maleimide-based covalent inhibitors of glycogen synthase kinase 3β
Yang, Zhimin,Liu, Hui,Pan, Botao,He, Fengli,Pan, Zhengying
supporting information, p. 4127 - 4140 (2018/06/12)
As an important kinase in multiple signal transduction pathways, GSK-3β has been an attractive target for chemical probe discovery and drug development. Compared to numerous reversible inhibitors that have been developed, covalent inhibitors of GSK-3β are
Three oxidative metabolites of indole-3-acetic acid from Arabidopsis thaliana
Kai, Kenji,Horita, Junko,Wakasa, Kyo,Miyagawa, Hisashi
, p. 1651 - 1663 (2008/02/05)
Three metabolites of indole-3-acetic acid (IAA), N-(6-hydroxyindol-3-ylacetyl)-phenylalanine (6-OH-IAA-Phe), N-(6-hydroxyindol-3-ylacetyl)-valine (6-OH-IAA-Val), and 1-O-(2-oxoindol-3-ylacetyl)-β-d-glucopyranose (OxIAA-Glc), were found by a liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS)-based search for oxidative IAA metabolites during the vegetative growth of Arabidopsis. Their structures were confirmed by making a comparison of chromatographic characteristics and mass spectra between naturally occurring compounds and synthetic standards. An incorporation study using deuterium-labeled compounds showed that 6-OH-IAA-Phe and 6-OH-IAA-Val were biosynthesized from IAA-Phe and IAA-Val, respectively, which strongly suggested the formation of these amino acid conjugates of IAA in plants. Both 6-OH-IAA-Phe and 6-OH-IAA-Val were inactive as auxins, as indicated by no significant root growth inhibition in Arabidopsis. Quantitative analysis demonstrated that OxIAA-Glc was present in the largest amount among the metabolites of IAA in Arabidopsis, suggesting that the conversion into OxIAA-Glc represents the main metabolic process regarding IAA in Arabidopsis.
Synthetic Approaches to Indolo[6,7-α]pyrrolo[3,4-c]carbazoles: Potent Cyclin D1/CDK4 Inhibitors
Faul, Margaret M.,Engler, Thomas A.,Sullivan, Kevin A.,Grutsch, John L.,Clayton, Marcella T.,Martinelli, Michael J.,Pawlak, Joseph M.,LeTourneau, Michael,Coffey, D. Scott,Pedersen, Steven W.,Kolis, Stanley P.,Furness, Kelly,Malhotra, Sushant,Al-Awar, Rima S.,Ray, James E.
, p. 2967 - 2975 (2008/04/18)
Synthesis of indolo[6,7-α]pyrrolo[3,4-c]carbazoles 1, a new class of cyclin D1/CDK4 inhibitors, by oxidation of the corresponding aryl indolylmaleimides 2, will be described. Two approaches to the synthesis of 2 were identified that required new methods f
