408365-47-9

Upstream product

• 408365-72-0 N-(4-nitrophenyl)-4'-(trifluoromethyl)-1,1'-biphenyl-2-carboxamide 
• 408365-67-3 4-nitro-N-(pyridin-2-ylmethyl)aniline 
• 408365-49-1 N-(3-nitrobenzyl)-2-pyridinecarboxamide 
• 408365-60-6 tert-butyl 4-nitrophenyl[2-(2-pyridinyl)ethyl]carbamate 
• 408365-46-8 N-(4-nitrobenzyl)-2-pyridinecarboxamide 
• 98-98-6 2-Picolinic acid 
• 4403-71-8 (4-aminomethyl)aniline 

Downstream Products

• 408365-58-2 N-(4-{[(4'-methyl-1,1'-biphenyl-2-yl)carbonyl]amino}benzyl)-2-pyridinecarboxamide 
• 408365-53-7 N-[4-({2-[3-(Trifluoromethyl)anilino]benzoyl}amino)benzyl]-2-pyridinecarboxamide 
• 408365-48-0 N-[4-({[4'-(trifluoromethyl)-1,1'-biphenyl-2-yl]carbonyl}amino)benzyl]-2-pyridinecarboxamide 
• 408365-59-3 N-(4-{[(4'-Chloro-1,1'-biphenyl-2-yl)carbonyl]amino}-benzyl)-2-pyridinecarboxamide 
• 408365-52-6 N-{4-[(1,1'-biphenyl-2-ylcarbonyl)amino]benzyl}-2-pyridinecarboxamide 

Relevant academic research and scientific papers

NOVEL COMPOUNDS

There is provided a compound of formula (I): processes for the manufacture thereof, pharmaceutical compositions thereof and uses in therapy.

Benzamide compounds as apo b secretion inhibitors

The present invention relates to compounds of the formula (I) wherein R1 and R2 are each independently lower alkyl lower alkenyl, acyl, amino, lower alkoxy, lower cycloalkyloxy, aryl, aryloxy, sulfooxy, mercapto, sulfo, hydrogen, halogen, nitro, cyano or hydroxy, or may form a ring structure; Q1 is N or CH; L is optionally substituted unsaturated 3 to 10-membered heterocyclic group; X is optionally substituted monocyclic arylene or monocyclic heteroarylene; Y is -(A1)m-(A2)n-(A4)k-; Z is directbond, —CH2-, —NH— or —O—; and R is hydrogen or lower alkyl, or a salt thereof The compounds of the present invention inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.