40848-52-0

Basic information

• Product Name: Phthalazine, 1-chloro-4-(4-chlorophenyl)-
• CAS NO: 40848-52-0
• Molecular Formula: C14H8Cl2N2
• Molecular Weight: 275.137
• Mol File: 40848-52-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Phthalazine, 1-chloro-4-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phthalazine, 1-chloro-4-(4-chlorophenyl)-(40848-52-0)
• EPA Substance Registry System: Phthalazine, 1-chloro-4-(4-chlorophenyl)-(40848-52-0)

Safety Data

• Hazardous Substances Data: 40848-52-0(Hazardous Substances Data)

Upstream product

• 106-39-8 bromochlorobenzene 
• 4770-30-3 2-(dimethylamino)isoindoline-1,3-dione 
• 85-44-9 phthalic anhydride 
• 85-56-3 2-(4-chlorobenzoyl)benzoic acid 
• 51334-86-2 4-(4-chlorophenyl)-1-(2H)-phthalazinone 

Downstream Products

• 1025026-97-4 1-(2,6-dimethylphenoxy)-4-(4-chlorophenyl)phthalazine 
• 126008-80-8 4-(4'-chlorophenyl)-1-hydrazinophthalazine 
• 1207681-60-4 4-(4-chlorophenyl)-N-(4-(2-(2-(methylamino)ethylamino)pyrimidin-4-ylthio)phenyl)phthalazin-1-amine 
• 1071534-78-5 4-(4-(4-(4-chlorophenyl)phthalazin-1-ylamino)phenylthio)-N-methylpicolinamide 
• 1187875-70-2 4-(4-chlorophenyl)-N-(4-(2-cyclopropylpyrazolo[1,5-a]pyrimidin-7-ylthio)phenyl)phthalazin-1-amine 
• 1071528-67-0 N-(4-(1,5-naphthyridin-4-ylthio)phenyl)-4-(4-chlorophenyl)phthalazin-1-amine 
• 126008-93-3 6-(4-Chloro-phenyl)-3-(3,4-dimethoxy-phenyl)-[1,2,4]triazolo[3,4-a]phthalazine 
• 126008-85-3 N-[4-(4-Chloro-phenyl)-phthalazin-1-yl]-N'-[1-(2-nitro-phenyl)-meth-(Z)-ylidene]-hydrazine 
• 126008-95-5 6-(4-Chloro-phenyl)-3-(2-nitro-phenyl)-[1,2,4]triazolo[3,4-a]phthalazine 
• 126008-83-1 N-[4-(4-Chloro-phenyl)-phthalazin-1-yl]-N'-[1-(3,4-dimethoxy-phenyl)-meth-(Z)-ylidene]-hydrazine 
• 126008-92-2 6-(4-Chloro-phenyl)-3-(4-methoxy-phenyl)-[1,2,4]triazolo[3,4-a]phthalazine 
• 126008-82-0 N-[4-(4-Chloro-phenyl)-phthalazin-1-yl]-N'-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-hydrazine 
• 126008-94-4 6-(4-Chloro-phenyl)-3-p-tolyl-[1,2,4]triazolo[3,4-a]phthalazine 
• 126008-84-2 N-[4-(4-Chloro-phenyl)-phthalazin-1-yl]-N'-[1-p-tolyl-meth-(Z)-ylidene]-hydrazine 

Relevant articles and documents

Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents

Treatment of patients with triple-negative breast cancer (TNBC) is challenging due to the absence of well- defined molecular targets and the heterogeneity of such disease. In our endeavor to develop potent isatin-based anti-proliferative agents, we utiliz

Synthesis of 4-substituted chlorophthalazines, dihydrobenzoazepinediones, 2-pyrazolylbenzoic acid, and 2-pyrazolylbenzohydrazide via 3-substituted 3-hydroxyisoindolin-1-ones

Figure Persented: Herein we describe a general three-step synthesis of 4-substituted chlorophthalazines in good overall yields. In the key step, N,N-dimethylaminophthalimide (8a) directs the selective monoaddition of alkyl, aryl, and heteroaryl organometallic reagents to afford 3-substituted 3-hydroxyisoindolinones 9b, 9i-9am. Many of these hydroxyisoindolinones are converted to chlorophthalazines 1b-1v via reaction with hydrazine, followed by chlorination with POCl3. We have also discovered two novel transformations of 3-vinyl- and 3-alkynyl-3-hydroxyisoindolinones. Addition of vinyl organometallic reagents to N,N-dimethylaminophthalimide (8a) provided dihydrobenzoazepinediones 15a-15c via the proposed ring expansion of 3-vinyl-3-hydroxyisoindolinone intermediates. 3-Alkynyl-3-hydroxyisoindolinones react with hydrazine and substituted hydrazines to afford 2-pyrazolyl benzoic acids 16a-16d and 2-pyrazolyl benzohydrazides 17a-17g rather than the expected alkynyl phthalazinones.