4085-18-1

Basic information

• Product Name: 3-nitrobiphenyl-4-ylamine
• Synonyms: 3-nitrobiphenyl-4-ylamine;3-Nitrobiphenyl-4-amine;3-Nitro-4-biphenylaMine
• CAS NO: 4085-18-1
• Molecular Formula: C₁₂H₁₀N₂O₂
• Molecular Weight: 214.22
• EINECS: 223-813-4
• Mol File: 4085-18-1.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 382.1°Cat760mmHg
• Flash Point: 184.9°C
• Appearance: /
• Density: 1.268g/cm³
• CAS DataBase Reference: 3-nitrobiphenyl-4-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-nitrobiphenyl-4-ylamine(4085-18-1)
• EPA Substance Registry System: 3-nitrobiphenyl-4-ylamine(4085-18-1)

Safety Data

• Hazardous Substances Data: 4085-18-1(Hazardous Substances Data)

Usage

General Description

3-Nitrobiphenyl-4-ylamine is an organic compound with the chemical formula C12H10N2O2. It is a nitroaromatic amine, which means it contains both a nitro group and an amino group attached to a biphenyl structure. 3-Nitrobiphenyl-4-ylamine is often used in the manufacturing of dyes, pigments, and other industrial chemicals. It is also known to be a potential mutagen and carcinogen, posing health risks to those exposed to it. 3-Nitrobiphenyl-4-ylamine is listed as a hazardous substance by various regulatory authorities due to its toxic and potentially harmful properties.

InChI:InChI=1/C12H10N2O2/c13-11-7-6-10(8-12(11)14(15)16)9-4-2-1-3-5-9/h1-8H,13H2

Upstream product

• 5393-46-4 4-acetamido-3-nitro-biphenyl 
• 20691-72-9 4-iodo-2-nitroaniline 
• 98-80-6 phenylboronic acid 
• 51294-43-0 4-iodo-1,2-dinitro-benzene 
• 875-51-4 4-Bromo-2-nitroaniline 
• 4075-79-0 4-phenylacetanilide 
• 92-67-1 4-phenylalanine 
• 88-74-4 2-nitro-aniline 
• 100-63-0 phenylhydrazine 
• 833486-94-5 4-amino-3-nitrophenylboronic acid pinacol ester 
• 65690-69-9 N-([1,1'-biphenyl]-4-yl)-4-methylbenzenesulfonamide 
• 860568-11-2 N,N'-(3'-nitro-biphenyl-2,4'-diyl)-bis-acetamide 
• 591-50-4 iodobenzene 
• 78843-20-6 3,4-dinitro-1,1^,-biphenyl 

Downstream Products

• 860203-21-0 8-nitro-4,6-diphenyl-quinoline 
• 62686-15-1 9-phenylacenaphtho[1,2-b]quinoxaline 
• 68527-71-9 6-phenyl-8-aminoquinoline 
• 68527-70-8 6-phenyl-8-nitroquinoline 
• 763131-39-1 6-phenyl-1,2,4-benzotriazin-3-amine 1-oxide 
• 25877-73-0 5-phenyl-1H-benzo-[d][1.2.3]triazole 
• 1448350-08-0 N-(2-amino-4-phenylphenyl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide 
• 1448350-17-1 N-(2-nitro-4-phenylphenyl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide 
• 1255709-92-2 2-(2-cyclohexylvinyl)-5-phenyl-1H-benzimidazole 
• 1365108-77-5 C₂₁H₂₂N₂O₃ 
• 1352637-90-1 3,4-dimethoxy-N-(3-nitrobiphenyl-4-yl)benzamide 
• 1352637-91-2 3,5-dimethoxy-N-(3-nitrobiphenyl-4-yl)benzamide 

Relevant articles and documents

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Synthesis and biological evaluation of N-biphenyl-nicotinic based moiety compounds: A new class of antimitotic agents for the treatment of Hodgkin Lymphoma

We previously demonstrated that some N-biphenylanilides caused cell-cycle arrest at G2/M transition in breast cancer cells. Among them we choose three derivatives, namely PTA34, PTA73 and RS35 for experimentation in solid tumor cell lines, classical Hodgkin Lymphoma (cHL) cell lines and bona fide normal cell lines. Almost all tumor cells were sensitive to compounds in the nanomolar range whereas, they were not cytotoxic to normal ones. Interestingly the compounds caused a strong G2/M phase arrest in cHL cell lines, thus, here we investigated whether they affected the integrity of microtubules in such cells. We found that they induced a long prometaphase arrest, followed by induction of apoptosis which involved mitochondria. PTA73 and RS35 induced the mitotic arrest through the fragmentation of microtubules which prevented the kinethocore-mitotic spindle interaction and the exit from mitosis. PTA34 is instead a tubulin-targeting agent because it inhibited the tubulin polymerization as vinblastine. As such, PTA34 maintained the Cyclin B1-CDK1 regulatory complex activated during the G2/M arrest while inducing the inactivation of Bcl-2 through phosphorylation in Ser70, the degradation of Mcl-1 and a strong activation of BIML and BIMS proapoptotic isoforms. In addition PTA34 exerted an antiangiogenic effect by suppressing microvascular formation.

Organic compound and organic electroluminescent device containing same

The invention relates to an organic compound, which is characterized by having a structure as shown in (1), wherein L1 and L2 are respectively and independently selected from a single bond, a substituted or unsubstituted C6-C30 arylene group or a substituted or unsubstituted C3-C30 heteroarylene group; Arl and Ar2 are respectively and independently selected from a substituted or unsubstituted C6-C30 aryl group or a substituted or unsubstituted C3-C30 heteroaryl group; R is halogen, a cyano group, an alkyl group, a substituted or unsubstituted C6-C30 aryl group or a substituted or unsubstituted C3-C30 heteroaryl group; and n represents an integer of 0-3.

Synthesis of Structurally Diverse Benzotriazoles via Rapid Diazotization and Intramolecular Cyclization of 1,2-Aryldiamines

An operationally simple method has been developed for the preparation of N-unsubstituted benzotriazoles by diazotization and intramolecular cyclization of a wide range of 1,2-aryldiamines under mild conditions, using a polymer-supported nitrite reagent and p-tosic acid. The functional group tolerance of this approach was further demonstrated with effective activation and cyclization of N-alkyl, -aryl, and -acyl ortho-aminoanilines leading to the synthesis of N1-substituted benzotriazoles. The synthetic utility of this one-pot heterocyclization process was exemplified with the preparation of a number of biologically and medicinally important benzotriazole scaffolds, including an α-amino acid analogue.