740809-75-0Relevant academic research and scientific papers
Methods and compositions for treating cancer
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Page/Page column 14, (2010/02/15)
The invention provides compounds and methods for treating cancer. Exemplary compounds are multi-functional compounds with two different moieties connected by a linker. Compounds of the invention can activate one or more pathways that result in the inhibit
Design, synthesis, and evaluation of estradiol-linked genotoxicants as anti-cancer agents
Sharma,Marquis,Dinaut, A. Nicole,Hillier,Fedeles,Rye,Essigmann,Croy
, p. 3829 - 3833 (2007/10/03)
A series of bifunctional compounds was prepared consisting of 17β estradiol linked to a DNA damaging N,N-bis-(2-chloroethyl)aniline. The objective of our studies was to determine the characteristics of the linker that permitted both reaction with DNA and
A rationally designed genotoxin that selectively destroys estrogen receptor-positive breast cancer cells
Mitra, Kaushik,Marquis, John C.,Hillier, Shawn M.,Rye, Peter T.,Zayas, Beatriz,Lee, Annie S.,Essigmann, John M.,Croy, Robert G.
, p. 1862 - 1863 (2007/10/03)
We describe a novel strategy to increase the selective toxicity of genotoxic compounds. The strategy involves the synthesis of bifunctional molecules capable of forming DNA adducts that have high affinity for specific proteins in target cells. It is propo
