40854-02-2Relevant academic research and scientific papers
Synthesis of Polynitroadamantanes. Oxidations of Oximinoadamantanes
Archibald, T. G.,Baum, K.
, p. 4645 - 4649 (1988)
Adamantanes bearing gem-dinitro groups on bridge carbons were synthesized from oximinoadamantanes by reaction with nitric acid, or alternatively, by reaction with aqueous hypobromite, reduction of the intermediate gem-bromonitroadamantanes, and oxidative nitration.Reaction of oximinoadamantanes with hypohlorous acid gave anomolous gem-dichloro compounds instead of chloronitro derivatives.The presence of two gem-dinitro groups in 2,2,6,6-tetranitroadamantane markedly enhanced the density (1.75 g 1/cm) compared to the related open structure 2,2,6,6-tetranitrobicyclononane (1.45 g/cm).
Synthesis and Antiviral Activity Evaluation of Some Aminoadamantane Derivatives
Kolocouris, Nicolas,Foscolos, George B.,Kolocouris, Antonios,Marakos, Panayotis,Pouli, Nicole,et al.
, p. 2896 - 2902 (1994)
The synthesis of some spiro-2-amines and methanamines and some spiro is described.The title compounds were evaluated against a wide range of viruses (influenza A, influenza B, parainfluenza 3, RSV, HSV-1, TK-HSV-1, HSV-2, vaccinia, vesicular stomatitis, polio 1, coxsackie B4, sindbis, semliki forest, Reo 1, HIV-1, and HIV-2), and some of them (compounds 6b, 6c, 9a, 16a, 16b, and 17) inhibited the cytopathicity of influenza A virus at a concentration significantly lower than that of amantadine and also significantly lower than the concentrations at which they proved cytotoxic to the host cells.None of the new aaminodmantane derivatives was active against influenza B virus or any of other viruses tested, which points to their specificity as anti-influenza A virus agents.
Synthesis of β-nitro ketones from geminal bromonitroalkanes and silyl enol ethers by visible light photoredox catalysis
Cao, Haoying,Ma, Shanshan,Feng, Yanhong,Guo, Yawen,Jiao, Peng
, p. 1780 - 1783 (2022/02/17)
Various β-nitro ketones, including those bearing a β-tertiary carbon, were prepared from geminal bromonitroalkanes and trimethylsilyl enol ethers of a broad range of ketones by visible light photoredox catalysis, which were then easily converted into β-amino ketones, 1,3-amino alcohols, α,β-unsaturated ketones, β-cyano ketones and γ-nitro ketones.
A new method for the one-step conversion of oximes into gem-halo-nitro derivatives
Curini, Massimo,Epifano, Francesco,Marcotullio, Maria Carla,Rosati, Ornelio,Rossi, Monia
, p. 6211 - 6218 (2007/10/03)
A mild and efficient process for one-step conversion of oximes into gem- halo-nitro compounds using Oxone and sodium chloride or potassium bromide is described.
New Reagents for the Synthesis of gem-Halonitro Compounds from Oximes
Walters, Thomas R.,Zajac, Walter W.,Woods, James M.
, p. 316 - 321 (2007/10/02)
The utility of the N-haloheterocycles 1-sodio-3,5-dichloro-1,3,5-triazine-2,4,6(1H,3H,5H)-trione (4), 1,3,5-trichloro-1,3,5-triazine-2,4,6(1H,3H,5H)-trione (5), 1,3-dibromo-1,3,5-triazine-2,4,6(1H,3H,5H)-trione (6), and 1,3-dibromo-5,5-dimethylhydantoin (
