Synthesis and Antiviral Activity Evaluation of Some Aminoadamantane Derivatives

Article abstract of DOI:10.1021/jm00044a010

The synthesis of some spiro-2-amines and methanamines and some spiro is described.The title compounds were evaluated against a wide range of viruses (influenza A, influenza B, parainfluenza 3, RSV, HSV-1, TK^-HSV-1, HSV-2, vaccinia, vesicular stomatitis, polio 1, coxsackie B4, sindbis, semliki forest, Reo 1, HIV-1, and HIV-2), and some of them (compounds 6b, 6c, 9a, 16a, 16b, and 17) inhibited the cytopathicity of influenza A virus at a concentration significantly lower than that of amantadine and also significantly lower than the concentrations at which they proved cytotoxic to the host cells.None of the new aaminodmantane derivatives was active against influenza B virus or any of other viruses tested, which points to their specificity as anti-influenza A virus agents.