40856-07-3

Basic information

• Product Name: difluoromethanesulphonic acid
• Synonyms: difluoromethanesulphonic acid;Difluoromethanesulfonic acid;Einecs 255-115-0
• CAS NO: 40856-07-3
• Molecular Formula: CH₂F₂O₃S
• Molecular Weight: 132.0865864
• EINECS: 255-115-0
• Mol File: 40856-07-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.764g/cm³
• Refractive Index: 1.377
• PKA: -2.03±0.50(Predicted)
• CAS DataBase Reference: difluoromethanesulphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: difluoromethanesulphonic acid(40856-07-3)
• EPA Substance Registry System: difluoromethanesulphonic acid(40856-07-3)

Safety Data

• Hazardous Substances Data: 40856-07-3(Hazardous Substances Data)

Usage

General Description

Difluoromethanesulphonic acid, also known as CF2HSO3H, is a highly reactive and corrosive compound that is commonly used as a strong acid in various chemical reactions. It is a colorless, odorless liquid that is soluble in water and polar organic solvents. Difluoromethanesulphonic acid is used as a catalyst in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is also used in electroplating, as a strong oxidizing agent, and as a fluorinating agent. Due to its corrosive and toxic nature, proper handling and safety precautions are necessary when working with difluoromethanesulphonic acid.

InChI:InChI=1/CH2F2O3S/c2-1(3)7(4,5)6/h1H,(H,4,5,6)

Upstream product

• 1004-47-3 3-chlorotrifluoro-1,2-oxathietane 2,2-dioxide 
• 7732-18-5 water 
• 933-29-9 4-chlorotrifluoro-1,2-oxathietane 2,2-dioxide 
• 1554-47-8 difluoromethanesulfonyl fluoride 
• 2795-52-0 Sodium difluoromethanesulfonate 
• 1717-59-5 2,2-difluoro-2-(fluorosulfonyl)acetic acid 
• 75-45-6 Chlorodifluoromethane 

Downstream Products

• 1512-30-7 difluoromethylsulfonyl chloride 

Relevant articles and documents

DIFLUOROMETHANESULFONIC ACID. PART II. A TWO-STEP ROUTE TO THE FREE ACID FROM MONOHYDRATED SODIUM DIFLUOROMETHANESULFONATE

Anhydrous difluoromethanesulfonic acid ("diflic acid") can be obtained, in a two step procedure, from monohydrated sodium difluoromethanesulfonate, a very stable salt not easily dehydrated.In the first step, stable hydronium difluoromethanesulfoate is distilled from a mixture of CHF2SO3Na, H2O and pure sulfuric acid in a 86percent yield.In the second step, diluted oleum (10percent SO3), containing a slight excess of sulfur trioxide, is slowly dropped intohydroniumdifluoromethanesulfonate and anhydrous difluoromethanesulfonic acid is distilled from the resulting mixture in a 51percent yield.The use of more concentrated oleum and excess of sulfur trioxide causes a rather violent decomposition to gaseous products for which a chain mechanism is proposed.The same process is invoked to explain the more violent degradation of hydronium difluoromethanesulfonate observed with thionyl chloride.This chain reaction seems to be governed by the great ability of the α-acidic hydrogen to form hydrogen bonds.

AN IMPROVED METHOD FOR SYNTHESIZING DIFLUOROMETHANESULFONIC ACID

In the presence of catalytic amounts of sodium sulfate or sodium chloride, fluorosulfonyldifluoroacetic acid (1) was decarboxylated in CH3CN-H2O to give difluoromethanesulfonyl fluoride (2) in moderate yield. 2 can be completely hydrolyzed to the corresponding acid 3 at 80 deg C to 100 deg C.The overall yield of 3 from 1 was 53percent.