40856-07-3

Usage

Uses

Used in Organic Synthesis:
Difluoromethanesulphonic acid is used as a catalyst for [accelerating the rate of chemical reactions] in the production of pharmaceuticals and agrochemicals.
Used in Electroplating:
Difluoromethanesulphonic acid is used as a strong oxidizing agent for [enhancing the electroplating process].
Used in Fluorination Processes:
Difluoromethanesulphonic acid is used as a fluorinating agent for [introducing fluorine atoms into organic compounds].
Used in Various Industries:
In the chemical industry, difluoromethanesulphonic acid is used as a strong acid for [various chemical reactions requiring a potent acid].
Safety Precautions:
Due to its corrosive and toxic nature, proper handling and safety precautions are necessary when working with difluoromethanesulphonic acid to [prevent harm to individuals and the environment].

InChI:InChI=1/CH2F2O3S/c2-1(3)7(4,5)6/h1H,(H,4,5,6)

Upstream product

• 1717-59-5 2,2-difluoro-2-(fluorosulfonyl)acetic acid 
• 2795-52-0 Sodium difluoromethanesulfonate 
• 1554-47-8 difluoromethanesulfonyl fluoride 
• 1004-47-3 3-chlorotrifluoro-1,2-oxathietane 2,2-dioxide 
• 7732-18-5 water 
• 933-29-9 4-chlorotrifluoro-1,2-oxathietane 2,2-dioxide 
• 75-45-6 Chlorodifluoromethane 

Downstream Products

• 1512-30-7 difluoromethylsulfonyl chloride 

Relevant academic research and scientific papers

DIFLUOROMETHANESULFONIC ACID. PART II. A TWO-STEP ROUTE TO THE FREE ACID FROM MONOHYDRATED SODIUM DIFLUOROMETHANESULFONATE

Anhydrous difluoromethanesulfonic acid ("diflic acid") can be obtained, in a two step procedure, from monohydrated sodium difluoromethanesulfonate, a very stable salt not easily dehydrated.In the first step, stable hydronium difluoromethanesulfoate is distilled from a mixture of CHF2SO3Na, H2O and pure sulfuric acid in a 86percent yield.In the second step, diluted oleum (10percent SO3), containing a slight excess of sulfur trioxide, is slowly dropped intohydroniumdifluoromethanesulfonate and anhydrous difluoromethanesulfonic acid is distilled from the resulting mixture in a 51percent yield.The use of more concentrated oleum and excess of sulfur trioxide causes a rather violent decomposition to gaseous products for which a chain mechanism is proposed.The same process is invoked to explain the more violent degradation of hydronium difluoromethanesulfonate observed with thionyl chloride.This chain reaction seems to be governed by the great ability of the α-acidic hydrogen to form hydrogen bonds.

Zn(ODf)2: Preparation and application in asymmetric alkynylation of aldehydes

A new Lewis acid, Zn(ODf)2, was first prepared from commercially available 3,3,4,4-tetrafluoro[1,2]oxathietane 2,2-dioxide in four steps with 56% yields and also was applied to catalyze highly enantioselective alkynylation of aldehydes in the presence of ligand (1S,2S)-3-(tert-butyldimethylsilyloxyl)-2-N,N-dimethylamino-1-(p- nitrophenyl)-propane-1-ol or ligand (-)-N-methylephedrine to afford the corresponding propargylic alcohols in high yields with up to 99% ee.

AN IMPROVED METHOD FOR SYNTHESIZING DIFLUOROMETHANESULFONIC ACID

In the presence of catalytic amounts of sodium sulfate or sodium chloride, fluorosulfonyldifluoroacetic acid (1) was decarboxylated in CH3CN-H2O to give difluoromethanesulfonyl fluoride (2) in moderate yield. 2 can be completely hydrolyzed to the corresponding acid 3 at 80 deg C to 100 deg C.The overall yield of 3 from 1 was 53percent.